Twisted gastrulation protein homolog 1
1_MKLHY 6_ VAVLT 11_ LAILM 16_ FLTWL 21_ PESLS 26_ CNKAL 31_ CASDV 36_ SKCLI 41_ QELCQ 46_ CRPGE 51_ GNCSC 56_ CKECM 61_ LCLGA 66_ LWDEC 71_ CDCVG 76_ MCNPR 81_ NYSDT 86_ PPTSK 91_ STVEE 96_ LHEPI 101_ PSLFR 106_ ALTEG 111_ DTQLN 116_ WNIVS 121_ FPVAE 126_ ELSHH 131_ ENLVS 136_ FLETV 141_ NQPHH 146_ QNVSV 151_ PSNNV 156_ HAPYS 161_ SDKEH 166_ MCTVV 171_ YFDDC 176_ MSIHQ 181_ CKISC 186_ ESMGA 191_ SKYRW 196_ FHNAC 201_ CECIG 206_ PECID 211_ YGSKT 216_VKCMN
1: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity)