Gene name: COA1

Uniprot entry:

Q9GZY4

Protein names:

Cytochrome c oxidase assembly factor 1 homolog (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa)

Protein sequence:

1_MMWQK 6_ YAGSR 11_ RSMPL 16_ GARIL 21_ FHGVF 26_ YAGGF 31_ AIVYY 36_ LIQKF 41_ HSRAL 46_ YYKLA 51_ VEQLQ 56_ SHPEA 61_ QEALG 66_ PPLNI 71_ HYLKL 76_ IDREN 81_ FVDIV 86_ DAKLK 91_ IPVSG 96_ SKSEG 101_ LLYVH 106_ SSRGG 111_ PFQRW 116_ HLDEV 121_ FLELK 126_ DGQQI 131_ PVFKL 136_ SGENG 141_DEVKK

Protein annotations

Protein functions:

1: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV (PubMed:23260140). As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I (PubMed:32320651)