Neuronal acetylcholine receptor subunit alpha-10 (Nicotinic acetylcholine receptor subunit alpha-10) (NACHR alpha-10)
1_MGLRS 6_ HHLSL 11_ GLLLL 16_ FLLPA 21_ ECLGA 26_ EGRLA 31_ LKLFR 36_ DLFAN 41_ YTSAL 46_ RPVAD 51_ TDQTL 56_ NVTLE 61_ VTLSQ 66_ IIDMD 71_ ERNQV 76_ LTLYL 81_ WIRQE 86_ WTDAY 91_ LRWDP 96_ NAYGG 101_ LDAIR 106_ IPSSL 111_ VWRPD 116_ IVLYN 121_ KADAQ 126_ PPGSA 131_ STNVV 136_ LRHDG 141_ AVRWD 146_ APAIT 151_ RSSCR 156_ VDVAA 161_ FPFDA 166_ QHCGL 171_ TFGSW 176_ THGGH 181_ QLDVR 186_ PRGAA 191_ ASLAD 196_ FVENV 201_ EWRVL 206_ GMPAR 211_ RRVLT 216_ YGCCS 221_ EPYPD 226_ VTFTL 231_ LLRRR 236_ AAAYV 241_ CNLLL 246_ PCVLI 251_ SLLAP 256_ LAFHL 261_ PADSG 266_ EKVSL 271_ GVTVL 276_ LALTV 281_ FQLLL 286_ AESMP 291_ PAESV 296_ PLIGK 301_ YYMAT 306_ MTMVT 311_ FSTAL 316_ TILIM 321_ NLHYC 326_ GPSVR 331_ PVPAW 336_ ARALL 341_ LGHLA 346_ RGLCV 351_ RERGE 356_ PCGQS 361_ RPPEL 366_ SPSPQ 371_ SPEGG 376_ AGPPA 381_ GPCHE 386_ PRCLC 391_ RQEAL 396_ LHHVA 401_ TIANT 406_ FRSHR 411_ AAQRC 416_ HEDWK 421_ RLARV 426_ MDRFF 431_ LAIFF 436_ SMALV 441_MSLLV
1: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (Probable). Forms heteropentamers with CHRNA9. Expressed in the inner ear, in sympathetic neurons and in other non-neuronal cells, such as skin keratinocytes and lymphocytes (PubMed:11752216, PubMed:15531379). nAChR formed by CHRNA9:CHRNA10 is involved in modulation of auditory stimuli. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, mediates synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing (PubMed:11752216). This may protect against acoustic trauma. May also regulate keratinocyte adhesion (By similarity)