E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2)
1_MSTKQ 6_ ITCRY 11_ FMHGV 16_ CREGS 21_ QCLFS 26_ HDLAN 31_ SKPST 36_ ICKYY 41_ QKGYC 46_ AYGTR 51_ CRYDH 56_ TRPSA 61_ AAGGA 66_ VGTMA 71_ HSVPS 76_ PAFHS 81_ PHPPS 86_ EVTAS 91_ IVKTN 96_ SHEPG 101_ KREKR 106_ TLVLR 111_ DRNLS 116_ GMAER 121_ KTQPS 126_ MVSNP 131_ GSCSD 136_ PQPSP 141_ EMKPH 146_ SYLDA 151_ IRSGL 156_ DDVEA 161_ SSSYS 166_ NEQQL 171_ CPYAA 176_ AGECR 181_ FGDAC 186_ VYLHG 191_ EVCEI 196_ CRLQV 201_ LHPFD 206_ PEQRK 211_ AHEKI 216_ CMLTF 221_ EHEME 226_ KAFAF 231_ QASQD 236_ KVCSI 241_ CMEVI 246_ LEKAS 251_ ASERR 256_ FGILS 261_ NCNHT 266_ YCLSC 271_ IRQWR 276_ CAKQF 281_ ENPII 286_ KSCPE 291_ CRVIS 296_ EFVIP 301_ SVYWV 306_ EDQNK 311_ KNELI 316_ EAFKQ 321_ GMGKK 326_ ACKYF 331_ EQGKG 336_ TCPFG 341_ SKCLY 346_ RHAYP 351_ DGRLA 356_ EPEKP 361_ RKQLS 366_ SQGTV 371_ RFFNS 376_ VRLWD 381_ FIENR 386_ ESRHV 391_ PNNED 396_ VDMTE 401_ LGDLF 406_ MHLSG 411_VESSE
1: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses (By similarity). Plays a role in the regulation of spermiation and in male fertility (By similarity)