Nascent polypeptide-associated complex subunit alpha-2 (Alpha-NAC-like) (Hom s 2.01) (Nascent polypeptide-associated complex subunit alpha-like) (NAC-alpha-like)
1_MPGEA 6_ TETVP 11_ ATEQE 16_ LPQSQ 21_ AETGS 26_ GTASD 31_ SGESV 36_ PGIEE 41_ QDSTQ 46_ TTTQK 51_ AWLVA 56_ AAEID 61_ EEPVG 66_ KAKQS 71_ RSEKR 76_ ARKAM 81_ SKLGL 86_ LQVTG 91_ VTRVT 96_ IWKSK 101_ NILFV 106_ ITKLD 111_ VYKSP 116_ ASDAY 121_ IVFGE 126_ AKIQD 131_ LSQQA 136_ QLAAA 141_ EKFRV 146_ QGEAV 151_ GNIQE 156_ NTQTP 161_ TVQEE 166_ SEEEE 171_ VDETG 176_ VEVKD 181_ VKLVM 186_ SQANV 191_ SRAKA 196_ VRALK 201_ NNSND 206_IVNAI
1: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity)