Repressor of RNA polymerase III transcription MAF1 homolog
1_MKLLE 6_ NSSFE 11_ AINSQ 16_ LTVET 21_ GDAHI 26_ IGRIE 31_ SYSCK 36_ MAGDD 41_ KHMFK 46_ QFCQE 51_ GQPHV 56_ LEALS 61_ PPQTS 66_ GLSPS 71_ RLSKS 76_ QGGEE 81_ EGPLS 86_ DKCSR 91_ KTLFY 96_ LIATL 101_ NESFR 106_ PDYDF 111_ STARS 116_ HEFSR 121_ EPSLS 126_ WVVNA 131_ VNCSL 136_ FSAVR 141_ EDFKD 146_ LKPQL 151_ WNAVD 156_ EEICL 161_ AECDI 166_ YSYNP 171_ DLDSD 176_ PFGED 181_ GSLWS 186_ FNYFF 191_ YNKRL 196_ KRIVF 201_ FSCRS 206_ ISGST 211_ YTPSE 216_ AGNEL 221_ DMELG 226_ EEEVE 231_ EESRS 236_ GGSGA 241_ EETST 246_ MEEDR 251_VPVIC
1: Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (PubMed:18377933, PubMed:20233713, PubMed:20516213, PubMed:20543138). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB (PubMed:17505538, PubMed:20887893). When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout (PubMed:26941251). Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (PubMed:17499043)