Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1)
1_MSDGF 6_ DRAPG 11_ AGRGR 16_ SRGLG 21_ RGGGG 26_ PEGGG 31_ FPNGA 36_ GPAER 41_ ARHQP 46_ PQPKA 51_ PGFLQ 56_ PPPLR 61_ QPRTT 66_ PPPGA 71_ QCEVP 76_ ASPQR 81_ PSRPG 86_ ALPEQ 91_ TRPLR 96_ APPSS 101_ QDKIP 106_ QQNSE 111_ SAMAK 116_ PQVVV 121_ APVLM 126_ SKLSV 131_ NAPEF 136_ YPSGY 141_ SSSYT 146_ ESYED 151_ GCEDY 156_ PTLSE 161_ YVQDF 166_ LNHLT 171_ EQPGS 176_ FETEI 181_ EQFAE 186_ TLNGC 191_ VTTDD 196_ ALQEL 201_ VELIY 206_ QQATS 211_ IPNFS 216_ YMGAR 221_ LCNYL 226_ SHHLT 231_ ISPQS 236_ GNFRQ 241_ LLLQR 246_ CRTEY 251_ EVKDQ 256_ AAKGD 261_ EVTRK 266_ RFHAF 271_ VLFLG 276_ ELYLN 281_ LEIKG 286_ TNGQV 291_ TRADI 296_ LQVGL 301_ RELLN 306_ ALFSN 311_ PMDDN 316_ LICAV 321_ KLLKL 326_ TGSVL 331_ EDAWK 336_ EKGKM 341_ DMEEI 346_ IQRIE 351_ NVVLD 356_ ANCSR 361_ DVKQM 366_ LLKLV 371_ ELRSS 376_ NWGRV 381_ HATST 386_ YREAT 391_ PENDP 396_ NYFMN 401_ EPTFY 406_ TSDGV 411_ PFTAA 416_ DPDYQ 421_ EKYQE 426_ LLERE 431_ DFFPD 436_ YEENG 441_ TDLSG 446_ AGDPY 451_ LDDID 456_ DEMDP 461_ EIEEA 466_ YEKFC 471_LESER
1: Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain
2: (Microbial infection) Upon interaction with SARS coronavirus SARS-CoV NSP3 protein, plays an important role in viral protein synthesis