Caseinolytic peptidase B protein homolog (EC 3.6.1.-) (Suppressor of potassium transport defect 3)
1_MLGSL 6_ VLRRK 11_ ALAPR 16_ LLLRL 21_ LRSPT 26_ LRGHG 31_ GASGR 36_ NVTTG 41_ SLGEP 46_ QWLRV 51_ ATGGR 56_ PGTSP 61_ ALFSG 66_ RGAAT 71_ GGRQG 76_ GRFDT 81_ KCLAA 86_ ATWGR 91_ LPGPE 96_ ETLPG 101_ QDSWN 106_ GVPSR 111_ AGLGM 116_ CALAA 121_ ALVVH 126_ CYSKS 131_ PSNKD 136_ AALLE 141_ AARAN 146_ NMQEV 151_ SRLLS 156_ EGADV 161_ NAKHR 166_ LGWTA 171_ LMVAA 176_ INRNN 181_ SVVQV 186_ LLAAG 191_ ADPNL 196_ GDDFS 201_ SVYKT 206_ AKEQG 211_ IHSLE 216_ DGGQD 221_ GASRH 226_ ITNQW 231_ TSALE 236_ FRRWL 241_ GLPAG 246_ VLITR 251_ EDDFN 256_ NRLNN 261_ RASFK 266_ GCTAL 271_ HYAVL 276_ ADDYR 281_ TVKEL 286_ LDGGA 291_ NPLQR 296_ NEMGH 301_ TPLDY 306_ AREGE 311_ VMKLL 316_ RTSEA 321_ KYQEK 326_ QRKRE 331_ AEERR 336_ RFPLE 341_ QRLKE 346_ HIIGQ 351_ ESAIA 356_ TVGAA 361_ IRRKE 366_ NGWYD 371_ EEHPL 376_ VFLFL 381_ GSSGI 386_ GKTEL 391_ AKQTA 396_ KYMHK 401_ DAKKG 406_ FIRLD 411_ MSEFQ 416_ ERHEV 421_ AKFIG 426_ SPPGY 431_ VGHEE 436_ GGQLT 441_ KKLKQ 446_ CPNAV 451_ VLFDE 456_ VDKAH 461_ PDVLT 466_ IMLQL 471_ FDEGR 476_ LTDGK 481_ GKTID 486_ CKDAI 491_ FIMTS 496_ NVASD 501_ EIAQH 506_ ALQLR 511_ QEALE 516_ MSRNR 521_ IAENL 526_ GDVQI 531_ SDKIT 536_ ISKNF 541_ KENVI 546_ RPILK 551_ AHFRR 556_ DEFLG 561_ RINEI 566_ VYFLP 571_ FCHSE 576_ LIQLV 581_ NKELN 586_ FWAKR 591_ AKQRH 596_ NITLL 601_ WDREV 606_ ADVLV 611_ DGYNV 616_ HYGAR 621_ SIKHE 626_ VERRV 631_ VNQLA 636_ AAYEQ 641_ DLLPG 646_ GCTLR 651_ ITVED 656_ SDKQL 661_ LKSPE 666_ LPSPQ 671_ AEKRL 676_ PKLRL 681_ EIIDK 686_ DSKTR 691_ RLDIR 696_ APLHP 701_EKVCN
1: Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins (PubMed:32573439, PubMed:34115842, PubMed:35247700, PubMed:36170828, PubMed:36745679). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). Plays a role in granulocyte differentiation (PubMed:34115842)