Ras-related protein Rab-33B
1_MAEEM 6_ ESSLE 11_ ASFSS 16_ SGAVS 21_ GASGF 26_ LPPAR 31_ SRIFK 36_ IIVIG 41_ DSNVG 46_ KTCLT 51_ YRFCA 56_ GRFPD 61_ RTEAT 66_ IGVDF 71_ RERAV 76_ EIDGE 81_ RIKIQ 86_ LWDTA 91_ GQERF 96_ RKSMV 101_ QHYYR 106_ NVHAV 111_ VFVYD 116_ MTNMA 121_ SFHSL 126_ PSWIE 131_ ECKQH 136_ LLAND 141_ IPRIL 146_ VGNKC 151_ DLRSA 156_ IQVPT 161_ DLAQK 166_ FADTH 171_ SMPLF 176_ ETSAK 181_ NPNDN 186_ DHVEA 191_ IFMTL 196_ AHKLK 201_ SHKPL 206_ MLSQP 211_ PDNGI 216_ ILKPE 221_PKPAM
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20163571, PubMed:21808068). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:18448665, PubMed:20163571, PubMed:21808068). RAB33B acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (PubMed:20163571). Participates in autophagosome formation by recruiting the ATG12-ATG5-ATG16L1 complex to phagophores, probably in a nucleotide-independent manner (PubMed:18448665, PubMed:32960676)