Dynein regulatory complex protein 9 (IQ domain-containing protein G)
1_MEEDS 6_ LEDSN 11_ LPPKV 16_ WHSEM 21_ TVSVT 26_ GEPPS 31_ TVEEE 36_ GIPKE 41_ TDIEI 46_ IPEIP 51_ ETLEP 56_ LSLPD 61_ VLRIS 66_ AVLED 71_ TTDQL 76_ SILNY 81_ IMPVQ 86_ YEGRQ 91_ SICVK 96_ SREMN 101_ LEGTN 106_ LDKLP 111_ MASTI 116_ TKIPS 121_ PLITE 126_ EGPNL 131_ PEIRH 136_ RGRFA 141_ VEFNK 146_ MQDLV 151_ FKKPT 156_ RQTIM 161_ TTETL 166_ KKIQI 171_ DRQFF 176_ SDVIA 181_ DTIKE 186_ LQDSA 191_ TYNSL 196_ LQALS 201_ KEREN 206_ KMHFY 211_ DIIAR 216_ EEKGR 221_ KQIIS 226_ LQKQL 231_ INVKK 236_ EWQFE 241_ VQSQN 246_ EYIAN 251_ LKDQL 256_ QEMKA 261_ KSNLE 266_ NRYMK 271_ TNTEL 276_ QIAQT 281_ QKKCN 286_ RTEEL 291_ LVEEI 296_ EKLRM 301_ KTEEE 306_ ARTHT 311_ EIEMF 316_ LRKEQ 321_ QKLEE 326_ RLEFW 331_ MEKYD 336_ KDTEM 341_ KQNEL 346_ NALKA 351_ TKASD 356_ LAHLQ 361_ DLAKM 366_ IREYE 371_ QVIIE 376_ DRIEK 381_ ERSKK 386_ KVKQD 391_ LLELK 396_ SVIKL 401_ QAWWR 406_ GTMIR 411_ REIGG 416_ FKMPK 421_ DKVDS 426_ KDSKG 431_ KGKGK 436_DKRRG
1: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility