RNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP)
1_MHRKK 6_ VDNRI 11_ RILIE 16_ NGVAE 21_ RQRSL 26_ FVVVG 31_ DRGKD 36_ QVVIL 41_ HHMLS 46_ KATVK 51_ ARPSV 56_ LWCYK 61_ KELGF 66_ SSHRK 71_ KRMRQ 76_ LQKKI 81_ KNGTL 86_ NIKQD 91_ DPFEL 96_ FIAAT 101_ NIRYC 106_ YYNET 111_ HKILG 116_ NTFGM 121_ CVLQD 126_ FEALT 131_ PNLLA 136_ RTVET 141_ VEGGG 146_ LVVIL 151_ LRTMN 156_ SLKQL 161_ YTVTM 166_ DVHSR 171_ YRTEA 176_ HQDVV 181_ GRFNE 186_ RFILS 191_ LASCK 196_ KCLVI 201_ DDQLN 206_ ILPIS 211_ SHVAT 216_ MEALP 221_ PQTPD 226_ ESLGP 231_ SDLEL 236_ RELKE 241_ SLQDT 246_ QPVGV 251_ LVDCC 256_ KTLDQ 261_ AKAVL 266_ KFIEG 271_ ISEKT 276_ LRSTV 281_ ALTAA 286_ RGRGK 291_ SAALG 296_ LAIAG 301_ AVAFG 306_ YSNIF 311_ VTSPS 316_ PDNLH 321_ TLFEF 326_ VFKGF 331_ DALQY 336_ QEHLD 341_ YEIIQ 346_ SLNPE 351_ FNKAV 356_ IRVNV 361_ FREHR 366_ QTIQY 371_ IHPAD 376_ AVKLG 381_ QAELV 386_ VIDEA 391_ AAIPL 396_ PLVKS 401_ LLGPY 406_ LVFMA 411_ STING 416_ YEGTG 421_ RSLSL 426_ KLIQQ 431_ LRQQS 436_ AQSQV 441_ STTAE 446_ NKTTT 451_ TARLA 456_ SARTL 461_ YEVSL 466_ QESIR 471_ YAPGD 476_ AVEKW 481_ LNDLL 486_ CLDCL 491_ NITRI 496_ VSGCP 501_ LPEAC 506_ ELYYV 511_ NRDTL 516_ FCYHK 521_ ASEVF 526_ LQRLM 531_ ALYVA 536_ SHYKN 541_ SPNDL 546_ QMLSD 551_ APAHH 556_ LFCLL 561_ PPVPP 566_ TQNAL 571_ PEVLA 576_ VIQVC 581_ LEGEI 586_ SRQSI 591_ LNSLS 596_ RGKKA 601_ SGDLI 606_ PWTVS 611_ EQFQD 616_ PDFGG 621_ LSGGR 626_ VVRIA 631_ VHPDY 636_ QGMGY 641_ GSRAL 646_ QLLQM 651_ YYEGR 656_ FPCLE 661_ EKVLE 666_ TPQEI 671_ HTVSS 676_ EAVSL 681_ LEEVI 686_ TPRKD 691_ LPPLL 696_ LKLNE 701_ RPAER 706_ LDYLG 711_ VSYGL 716_ TPRLL 721_ KFWKR 726_ AGFVP 731_ VYLRQ 736_ TPNDL 741_ TGEHS 746_ CIMLK 751_ TLTDE 756_ DEADQ 761_ GGWLA 766_ AFWKD 771_ FRRRF 776_ LALLS 781_ YQFST 786_ FSPSL 791_ ALNII 796_ QNRNM 801_ GKPAQ 806_ PALSR 811_ EELEA 816_ LFLPY 821_ DLKRL 826_ EMYSR 831_ NMVDY 836_ HLIMD 841_ MIPAI 846_ SRIYF 851_ LNQLG 856_ DLALS 861_ AAQSA 866_ LLLGI 871_ GLQHK 876_ SVDQL 881_ EKEIE 886_ LPSGQ 891_ LMGLF 896_ NRIIR 901_ KVVKL 906_ FNEVQ 911_ EKAIE 916_ EQMVA 921_ AKDVV 926_ MEPTM 931_ KTLSD 936_ DLDEA 941_ AKEFQ 946_ EKHKK 951_ EVGKL 956_ KSMDL 961_ SEYII 966_ RGDDE 971_ EWNEV 976_ LNKAG 981_ PNASI 986_ ISLKS 991_ DKKRK 996_ LEAKQ 1001_ EPKQS 1006_ KKLKN 1011_ RETKN 1016_KKDMK
1: RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs (PubMed:25411247, PubMed:25653167, PubMed:30449621, PubMed:35679869). Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation (PubMed:30449621, PubMed:35679869). mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency (PubMed:30449621). Mediates the formation of ac4C at position 1842 in 18S rRNA (PubMed:25411247). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25411247, PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro (PubMed:14592445, PubMed:17631499, PubMed:19303003, PubMed:26882543, PubMed:27993683, PubMed:30165671). The relevance of the protein lysine acetyltransferase activity is however unsure in vivo (PubMed:30449621). Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization (PubMed:14592445, PubMed:18082603). Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation (PubMed:31722219). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)