Gene name: COMMD4

Uniprot entry:

Q9H0A8

Protein names:

COMM domain-containing protein 4

Protein sequence:

1_MRFRF 6_ CGDLD 11_ CPDWV 16_ LAEIS 21_ TLAKM 26_ SSVKL 31_ RLLCS 36_ QVLKE 41_ LLGQG 46_ IDYEK 51_ ILKLT 56_ ADAKF 61_ ESGDV 66_ KATVA 71_ VLSFI 76_ LSSAA 81_ KHSVD 86_ GESLS 91_ SELQQ 96_ LGLPK 101_ EHAAS 106_ LCRCY 111_ EEKQS 116_ PLQKH 121_ LRVCS 126_ LRMNR 131_ LAGVG 136_ WRVDY 141_ TLSSS 146_ LLQSV 151_ EEPMV 156_ HLRLE 161_ VAAAP 166_ GTPAQ 171_ PVAMS 176_ LSADK 181_ FQVLL 186_ AELKQ 191_AQTLM

Protein annotations

Protein functions:

1: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B (PubMed:23637203)