Toll-interacting protein
1_MATTV 6_ STQRG 11_ PVYIG 16_ ELPQD 21_ FLRIT 26_ PTQQQ 31_ RQVQL 36_ DAQAA 41_ QQLQY 46_ GGAVG 51_ TVGRL 56_ NITVV 61_ QAKLA 66_ KNYGM 71_ TRMDP 76_ YCRLR 81_ LGYAV 86_ YETPT 91_ AHNGA 96_ KNPRW 101_ NKVIH 106_ CTVPP 111_ GVDSF 116_ YLEIF 121_ DERAF 126_ SMDDR 131_ IAWTH 136_ ITIPE 141_ SLRQG 146_ KVEDK 151_ WYSLS 156_ GRQGD 161_ DKEGM 166_ INLVM 171_ SYALL 176_ PAAMV 181_ MPPQP 186_ VVLMP 191_ TVYQQ 196_ GVGYV 201_ PITGM 206_ PAVCS 211_ PGMVP 216_ VALPP 221_ AAVNA 226_ QPRCS 231_ EEDLK 236_ AIQDM 241_ FPNMD 246_ QEVIR 251_ SVLEA 256_ QRGNK 261_ DAAIN 266_SLLQM
1: Component of the signaling pathway of IL-1 and Toll-like receptors (PubMed:10854325, PubMed:11751856). Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex (PubMed:10854325). Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (PubMed:25042851). The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:26320582)