Ubiquitin carboxyl-terminal hydrolase 44 (EC 3.4.19.12) (Deubiquitinating enzyme 44) (Ubiquitin thioesterase 44) (Ubiquitin-specific-processing protease 44)
1_MLAMD 6_ TCKHV 11_ GQLQL 16_ AQDHS 21_ SLNPQ 26_ KWHCV 31_ DCNTT 36_ ESIWA 41_ CLSCS 46_ HVACG 51_ RYIEE 56_ HALKH 61_ FQESS 66_ HPVAL 71_ EVNEM 76_ YVFCY 81_ LCDDY 86_ VLNDN 91_ TTGDL 96_ KLLRR 101_ TLSAI 106_ KSQNY 111_ HCTTR 116_ SGRFL 121_ RSMGT 126_ GDDSY 131_ FLHDG 136_ AQSLL 141_ QSEDQ 146_ LYTAL 151_ WHRRR 156_ ILMGK 161_ IFRTW 166_ FEQSP 171_ IGRKK 176_ QEEPF 181_ QEKIV 186_ VKREV 191_ KKRRQ 196_ ELEYQ 201_ VKAEL 206_ ESMPP 211_ RKSLR 216_ LQGLA 221_ QSTII 226_ EIVSV 231_ QVPAQ 236_ TPASP 241_ AKDKV 246_ LSTSE 251_ NEISQ 256_ KVSDS 261_ SVKRR 266_ PIVTP 271_ GVTGL 276_ RNLGN 281_ TCYMN 286_ SVLQV 291_ LSHLL 296_ IFRQC 301_ FLKLD 306_ LNQWL 311_ AMTAS 316_ EKTRS 321_ CKHPP 326_ VTDTV 331_ VYQMN 336_ ECQEK 341_ DTGFV 346_ CSRQS 351_ SLSSG 356_ LSGGA 361_ SKGRK 366_ MELIQ 371_ PKEPT 376_ SQYIS 381_ LCHEL 386_ HTLFQ 391_ VMWSG 396_ KWALV 401_ SPFAM 406_ LHSVW 411_ RLIPA 416_ FRGYA 421_ QQDAQ 426_ EFLCE 431_ LLDKI 436_ QRELE 441_ TTGTS 446_ LPALI 451_ PTSQR 456_ KLIKQ 461_ VLNVV 466_ NNIFH 471_ GQLLS 476_ QVTCL 481_ ACDNK 486_ SNTIE 491_ PFWDL 496_ SLEFP 501_ ERYQC 506_ SGKDI 511_ ASQPC 516_ LVTEM 521_ LAKFT 526_ ETEAL 531_ EGKIY 536_ VCDQC 541_ NSKRR 546_ RFSSK 551_ PVVLT 556_ EAQKQ 561_ LMICH 566_ LPQVL 571_ RLHLK 576_ RFRWS 581_ GRNNR 586_ EKIGV 591_ HVGFE 596_ EILNM 601_ EPYCC 606_ RETLK 611_ SLRPE 616_ CFIYD 621_ LSAVV 626_ MHHGK 631_ GFGSG 636_ HYTAY 641_ CYNSE 646_ GGFWV 651_ HCNDS 656_ KLSMC 661_ TMDEV 666_ CKAQA 671_ YILFY 676_ TQRVT 681_ ENGHS 686_ KLLPP 691_ ELLLG 696_ SQHPN 701_ EDADT 706_SSNEI
1: Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C) (PubMed:17443180). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C (PubMed:17443180). Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint (PubMed:17443180). Also promotes the deubiquitination of histone H2A and H2B (PubMed:23615962, PubMed:27880911). Recruited to RNF8/RNF168-ubiquitinated chromatin surrounding double stranded breaks (DSBs), promotes hydrolysis of such ubiquitin conjugates, thus negatively regulating protein recruitment to damaged chromatin (PubMed:23615962). Participates in nucleotide excision repair (NER) pathway by deubiquitinating DDB2 to prevent its premature degradation so it can remain on damaged chromatin (By similarity). Promotes FOXP3 stabilization through 'Lys-48'-linked deubiquitination leading to increased stability and increased regulatory T-cell lineage stability (PubMed:32644293). Also plays a positive role in innate immune response to DNA viruses by deubiquitinating STING1, selectively removing its 'Lys-48'-linked polyubiquitin chains and stabilizing it (PubMed:31968013)