Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120)
1_MATGT 6_ GKHKL 11_ LSTGP 16_ TEPWS 21_ IREKL 26_ CLASS 31_ VMRSG 36_ DQNWV 41_ SVSRA 46_ IKPFA 51_ EPGRP 56_ PDWFS 61_ QKHCA 66_ SQYSE 71_ LLETT 76_ ETPKR 81_ KRGEK 86_ GEVVE 91_ TVEDV 96_ IVRKL 101_ TAERV 106_ EELKK 111_ VIKET 116_ QERYR 121_ RLKRD 126_ AELIQ 131_ AGHMD 136_ SRLDE 141_ LCNDI 146_ ATKKK 151_ LEEEE 156_ AEVKR 161_ KATDA 166_ AYQAR 171_ QAVKT 176_ PPRRL 181_ PTVMV 186_ RSPID 191_ SASPG 196_ GDYPL 201_ GDLTP 206_ TTMEE 211_ ATSGV 216_ NESEM 221_ AVASG 226_ HLNST 231_ GVLLE 236_ VGGVL 241_ PMIHG 246_ GEIQQ 251_ TPNTV 256_ AASPA 261_ ASGAP 266_ TLSRL 271_ LEAGP 276_ TQFTT 281_ PLASF 286_ TTVAS 291_ EPPVK 296_ LVPPP 301_ VESVS 306_ QATIV 311_ MMPAL 316_ PAPSS 321_ APAVS 326_ TTESV 331_ APVSQ 336_ PDNCV 341_ PMEAV 346_ GDPHT 351_ VTVSM 356_ DSSEI 361_ SMIIN 366_ SIKEE 371_ CFRSG 376_ VAEAP 381_ VGSKA 386_ PSIDG 391_ KEELD 396_ LAEKM 401_ DIAVS 406_ YTGEE 411_ LDFET 416_ VGDII 421_ AIIED 426_ KVDDH 431_ PEVLD 436_ VAAVE 441_ AALSF 446_ CEEND 451_ DPQSL 456_ PGPWE 461_ HPIQQ 466_ ERDKP 471_ VPLPA 476_ PEMTV 481_ KQERL 486_ DFEET 491_ ENKGI 496_ HELVD 501_ IREPS 506_ AEIKV 511_ EPAEP 516_ EPVIS 521_ GAEIV 526_ AGVVP 531_ ATSME 536_ PPELR 541_ SQDLD 546_ EELGS 551_ TAAGE 556_ IVEAD 561_ VAIGK 566_ GDETP 571_ LTNVK 576_ TEASP 581_ ESMLS 586_ PSHGS 591_ NPIED 596_ PLEAE 601_ TQHKF 606_ EMSDS 611_ LKEES 616_ GTIFG 621_ SQIKD 626_ APGED 631_ EEEDG 636_ VSEAA 641_ SLEEP 646_ KEEDQ 651_ GEGYL 656_ SEMDN 661_ EPPVS 666_ ESDDG 671_ FSIHN 676_ ATLQS 681_ HTLAD 686_ SIPSS 691_ PASSQ 696_ FSVCS 701_ EDQEA 706_ IQAQK 711_ IWKKA 716_ IMLVW 721_ RAAAN 726_ HRYAN 731_ VFLQP 736_ VTDDI 741_ APGYH 746_ SIVQR 751_ PMDLS 756_ TIKKN 761_ IENGL 766_ IRSTA 771_ EFQRD 776_ IMLMF 781_ QNAVM 786_ YNSSD 791_ HDVYH 796_ MAVEM 801_ QRDVL 806_ EQIQQ 811_ FLATQ 816_ LIMQT 821_ SESGI 826_ SAKSL 831_ RGRDS 836_ TRKQD 841_ ASEKD 846_ SVPMG 851_ SPAFL 856_ LSLFM 861_ GHEWV 866_ WLDSE 871_ QDHPN 876_ DSELS 881_ NDCRS 886_ LFSSW 891_ DSSLD 896_ LDVGN 901_ WRETE 906_ DPEAE 911_ ELEES 916_ SPERE 921_ PSELL 926_ VGDGG 931_ SEESQ 936_ EAARK 941_ ASHQN 946_ LLHFL 951_ SEVAY 956_ LMEPL 961_ CISSN 966_ ESSEG 971_ CCPPS 976_ GTRQE 981_ GREIK 986_ ASEGE 991_ RELCR 996_ ETEEL 1001_ SAKGD 1006_ PLVAE 1011_ KPLGE 1016_ NGKPE 1021_ VASAP 1026_ SVICT 1031_ VQGLL 1036_ TESEE 1041_ GEAQQ 1046_ ESKGE 1051_ DQGEV 1056_ YVSEM 1061_ EDQPP 1066_ SGECD 1071_ DAFNI 1076_ KETPL 1081_ VDTLF 1086_ SHATS 1091_ SKLTD 1096_ LSQDD 1101_ PVQDH 1106_ LLFKK 1111_ TLLPV 1116_ WKMIA 1121_ SHRFS 1126_ SPFLK 1131_ PVSER 1136_ QAPGY 1141_ KDVVK 1146_ RPMDL 1151_ TSLKR 1156_ NLSKG 1161_ RIRTM 1166_ AQFLR 1171_ DLMLM 1176_ FQNAV 1181_ MYNDS 1186_ DHHVY 1191_ HMAVE 1196_ MRQEV 1201_ LEQIQ 1206_ VLNIW 1211_ LDKRK 1216_ GSSSL 1221_ EGEPA 1226_NPVDD
1: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome