ADP-ribosylation factor-like protein 6 (Bardet-Biedl syndrome 3 protein)
1_MGLLD 6_ RLSVL 11_ LGLKK 16_ KEVHV 21_ LCLGL 26_ DNSGK 31_ TTIIN 36_ KLKPS 41_ NAQSQ 46_ NILPT 51_ IGFSI 56_ EKFKS 61_ SSLSF 66_ TVFDM 71_ SGQGR 76_ YRNLW 81_ EHYYK 86_ EGQAI 91_ IFVID 96_ SSDRL 101_ RMVVA 106_ KEELD 111_ TLLNH 116_ PDIKH 121_ RRIPI 126_ LFFAN 131_ KMDLR 136_ DAVTS 141_ VKVSQ 146_ LLCLE 151_ NIKDK 156_ PWHIC 161_ ASDAI 166_ KGEGL 171_ QEGVD 176_ WLQDQ 181_IQTVK
1: Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (PubMed:20603001). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (PubMed:22072986). May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (PubMed:20207729). Isoform 2 may be required for proper retinal function and organization (By similarity)