Integrator complex subunit 2 (Int2)
1_MKDQQ 6_ TVIMT 11_ ECTSL 16_ QFVSP 21_ FAFEA 26_ MQKVD 31_ VVCLA 36_ SLSDP 41_ ELRLL 46_ LPCLV 51_ RMALC 56_ APADQ 61_ SQSWA 66_ QDKKL 71_ ILRLL 76_ SGVEA 81_ VNSIV 86_ ALLSV 91_ DFHAL 96_ EQDAS 101_ KEQQL 106_ RHKLG 111_ GGSGE 116_ SILVS 121_ QLQHG 126_ LTLEF 131_ EHSDS 136_ PRRLR 141_ LVLSE 146_ LLAIM 151_ NKVSE 156_ SNGEF 161_ FFKSS 166_ ELFES 171_ PVYLE 176_ EAADV 181_ LCILQ 186_ AELPS 191_ LLPIV 196_ DVAEA 201_ LLHVR 206_ NGAWF 211_ LCLLV 216_ ANVPD 221_ SFNEV 226_ CRGLI 231_ KNGER 236_ QDEES 241_ LGGRR 246_ RTDAL 251_ RFLCK 256_ MNPSQ 261_ ALKVR 266_ GMVVE 271_ ECHLP 276_ GLGVA 281_ LTLDH 286_ TKNEA 291_ CEDGV 296_ SDLVC 301_ FVSGL 306_ LLGTN 311_ AKVRT 316_ WFGTF 321_ IRNGQ 326_ QRKRE 331_ TSSSV 336_ LWQMR 341_ RQLLL 346_ ELMGI 351_ LPTVR 356_ STRIV 361_ EEADV 366_ DMEPN 371_ VSVYS 376_ GLKEE 381_ HVVKA 386_ SALLR 391_ LYCAL 396_ MGIAG 401_ LKPTE 406_ EEAEQ 411_ LLQLM 416_ TSRPP 421_ ATPAG 426_ VRFVS 431_ LSFCM 436_ LLAFS 441_ TLVST 446_ PEQEQ 451_ LMVVW 456_ LSWMI 461_ KEEAY 466_ FESTS 471_ GVSAS 476_ FGEML 481_ LLVAM 486_ YFHSN 491_ QLSAI 496_ IDLVC 501_ STLGM 506_ KIVIK 511_ PSSLS 516_ RMKTI 521_ FTQEI 526_ FTEQV 531_ VTAHA 536_ VRVPV 541_ TSNLS 546_ ANITG 551_ FLPIH 556_ CIYQL 561_ LRSRS 566_ FTKHK 571_ VSIKD 576_ WIYRQ 581_ LCETS 586_ TPLHP 591_ QLLPL 596_ IDVYI 601_ NSILT 606_ PASKS 611_ NPEAT 616_ NQPVT 621_ EQEIL 626_ NIFQG 631_ VIGGD 636_ NIRLN 641_ QRFSI 646_ TAQLL 651_ VLYYI 656_ LSYEE 661_ ALLAN 666_ TKTLA 671_ AMQRK 676_ PKSYS 681_ SSLMD 686_ QIPIK 691_ FLIRQ 696_ AQGLQ 701_ QELGG 706_ LHSAL 711_ LRLLA 716_ TNYPH 721_ LCIVD 726_ DWICE 731_ EEITG 736_ TDALL 741_ RRMLL 746_ TNNAK 751_ NHSPK 756_ QLQEA 761_ FSAVP 766_ VNNTQ 771_ VMQII 776_ EHLTL 781_ LSASE 786_ LIPYA 791_ EVLTS 796_ NMSQL 801_ LNSGV 806_ PRRIL 811_ QTVNK 816_ LWMVL 821_ NTVMP 826_ RRLWV 831_ MTVNA 836_ LQPSI 841_ KFVRQ 846_ QKYTQ 851_ NDLMI 856_ DPLIV 861_ LRCDQ 866_ RVHRC 871_ PPLMD 876_ ITLHM 881_ LNGYL 886_ LASKA 891_ YLSAH 896_ LKETE 901_ QDRPS 906_ QNNTI 911_ GLVGQ 916_ TDAPE 921_ VTREE 926_ LKNAL 931_ LAAQD 936_ SAAVQ 941_ ILLEI 946_ CLPTE 951_ EEKAN 956_ GVNPD 961_ SLLRN 966_ VQSVI 971_ TTSAP 976_ NKGME 981_ EGEDN 986_ LLCNL 991_ REVQC 996_ LICCL 1001_ LHQMY 1006_ IADPN 1011_ IAKLV 1016_ HFQGY 1021_ PCELL 1026_ PLTVA 1031_ GIPSM 1036_ HICLD 1041_ FIPEL 1046_ IAQPE 1051_ LEKQI 1056_ FAIQL 1061_ LSHLC 1066_ IQYAL 1071_ PKSLS 1076_ VARLA 1081_ VNVMG 1086_ TLLTV 1091_ LTQAK 1096_ RYAFF 1101_ MPTLP 1106_ SLVSF 1111_ CRAFP 1116_ PLYED 1121_ IMSLL 1126_ IQIGQ 1131_ VCASD 1136_ VATQT 1141_ RDIDP 1146_ IITRL 1151_ QQIKE 1156_ KPSGW 1161_ SQICK 1166_ DSSYK 1171_ NGSRD 1176_ TGSMD 1181_ PDVQL 1186_ CHCIE 1191_ RTVIE 1196_IINMS
1: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex (PubMed:23904267)