Kelch-like protein 25 (Ectoderm-neural cortex protein 2) (ENC-2)
1_MSVSV 6_ HETRK 11_ SRSST 16_ GSMNV 21_ TLFHK 26_ ASHPD 31_ CVLAH 36_ LNTLR 41_ KHCMF 46_ TDVTL 51_ WAGDR 56_ AFPCH 61_ RAVLA 66_ ASSRY 71_ FEAMF 76_ SHGLR 81_ ESRDD 86_ TVNFQ 91_ DNLHP 96_ EVLEL 101_ LLDFA 106_ YSSRI 111_ AINEE 116_ NAESL 121_ LEAGD 126_ MLQFH 131_ DVRDA 136_ AAEFL 141_ EKNLF 146_ PSNCL 151_ GMMLL 156_ SDAHQ 161_ CRRLY 166_ EFSWR 171_ MCLVH 176_ FETVR 181_ QSEDF 186_ NSLSK 191_ DTLLD 196_ LISSD 201_ ELETE 206_ DERVV 211_ FEAIL 216_ QWVKH 221_ DLEPR 226_ KVHLP 231_ ELLRS 236_ VRLAL 241_ LPSDC 246_ LQEAV 251_ SSEAL 256_ LMADE 261_ RTKLI 266_ MDEAL 271_ RCKTR 276_ ILQND 281_ GVVTS 286_ PCARP 291_ RKAGH 296_ TLLIL 301_ GGQTF 306_ MCDKI 311_ YQVDH 316_ KAKEI 321_ IPKAD 326_ LPSPR 331_ KEFSA 336_ SAIGC 341_ KVYVT 346_ GGRGS 351_ ENGVS 356_ KDVWV 361_ YDTVH 366_ EEWSK 371_ AAPML 376_ IARFG 381_ HGSAE 386_ LENCL 391_ YVVGG 396_ HTSLA 401_ GVFPA 406_ SPSVS 411_ LKQVE 416_ KYDPG 421_ ANKWM 426_ MVAPL 431_ RDGVS 436_ NAAVV 441_ SAKLK 446_ LFVFG 451_ GTSIH 456_ RDMVS 461_ KVQCY 466_ DPSEN 471_ RWTIK 476_ AECPQ 481_ PWRYT 486_ AAAVL 491_ GSQIF 496_ IMGGD 501_ TEFTA 506_ ASAYR 511_ FDCET 516_ NQWTR 521_ IGDMT 526_ AKRMS 531_ CHALA 536_ SGNKL 541_ YVVGG 546_ YFGTQ 551_ RCKTL 556_ DCYDP 561_ TSDTW 566_ NCITT 571_ VPYSL 576_ IPTAF 581_VSTWK
1: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis (PubMed:22578813, PubMed:27664236, PubMed:34491895). The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low (PubMed:22578813). The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E (PubMed:22578813). The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis (PubMed:27664236, PubMed:34491895). BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells (PubMed:34491895)