Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4)
1_MDTMM 6_ LNVRN 11_ LFEQL 16_ VRRVE 21_ ILSEG 26_ NEVQF 31_ IQLAK 36_ DFEDF 41_ RKKWQ 46_ RTDHE 51_ LGKYK 56_ DLLMK 61_ AETER 66_ SALDV 71_ KLKHA 76_ RNQVD 81_ VEIKR 86_ RQRAE 91_ ADCEK 96_ LERQI 101_ QLIRE 106_ MLMCD 111_ TSGSI 116_ QLSEE 121_ QKSAL 126_ AFLNR 131_ GQPSS 136_ SNAGN 141_ KRLST 146_ IDESG 151_ SILSD 156_ ISFDK 161_ TDESL 166_ DWDSS 171_ LVKTF 176_ KLKKR 181_ EKRRS 186_ TSRQF 191_ VDGPP 196_ GPVKK 201_ TRSIG 206_ SAVDQ 211_ GNESI 216_ VAKTT 221_ VTVPN 226_ DGGPI 231_ EAVST 236_ IETVP 241_ YWTRS 246_ RRKTG 251_ TLQPW 256_ NSDST 261_ LNSRQ 266_ LEPRT 271_ ETDSV 276_ GTPQS 281_ NGGMR 286_ LHDFV 291_ SKTVI 296_ KPESC 301_ VPCGK 306_ RIKFG 311_ KLSLK 316_ CRDCR 321_ VVSHP 326_ ECRDR 331_ CPLPC 336_ IPTLI 341_ GTPVK 346_ IGEGM 351_ LADFV 356_ SQTSP 361_ MIPSI 366_ VVHCV 371_ NEIEQ 376_ RGLTE 381_ TGLYR 386_ ISGCD 391_ RTVKE 396_ LKEKF 401_ LRVKT 406_ VPLLS 411_ KVDDI 416_ HAICS 421_ LLKDF 426_ LRNLK 431_ EPLLT 436_ FRLNR 441_ AFMEA 446_ AEITD 451_ EDNSI 456_ AAMYQ 461_ AVGEL 466_ PQANR 471_ DTLAF 476_ LMIHL 481_ QRVAQ 486_ SPHTK 491_ MDVAN 496_ LAKVF 501_ GPTIV 506_ AHAVP 511_ NPDPV 516_ TMLQD 521_ IKRQP 526_ KVVER 531_ LLSLP 536_ LEYWS 541_ QFMMV 546_ EQENI 551_ DPLHV 556_ IENSN 561_ AFSTP 566_ QTPDI 571_ KVSLL 576_ GPVTT 581_ PEHQL 586_ LKTPS 591_ SSSLS 596_ QRVRS 601_ TLTKN 606_ TPRFG 611_ SKSKS 616_ ATNLG 621_ RQGNF 626_FASPM
1: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis (PubMed:18511905). Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity (PubMed:10979956). Has a critical role in erythropoiesis (PubMed:34818416). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells