Enkurin domain-containing protein 1
1_MCEGP 6_ SRISG 11_ PIPPD 16_ PTLCP 21_ DNYRR 26_ PTSAQ 31_ GRLEG 36_ NALKL 41_ DLLTS 46_ DRALD 51_ TTAPR 56_ GPCIG 61_ PGAGE 66_ ILERG 71_ QRGVG 76_ DVLLQ 81_ LEGIS 86_ LGPGA 91_ SLKRK 96_ DPKDH 101_ EKENL 106_ RRIRE 111_ IQKRF 116_ REQER 121_ SREQG 126_ QPRPL 131_ KALWR 136_ SPKYD 141_ KVESR 146_ VKAQL 151_ QEPGP 156_ ASGTE 161_ SAHFL 166_ RAHSR 171_ CGPGL 176_ PPPHV 181_ SSPQP 186_ TPPGP 191_ EAKEP 196_ GLGVD 201_ FIRHN 206_ ARAAK 211_ RAPRR 216_ HSCSL 221_ QVLAQ 226_ VLEQQ 231_ RQAQE 236_ HYNAT 241_ QKGHV 246_ PHYLL 251_ ERRDL 256_ WRREA 261_ EARKQ 266_ SQPDP 271_ AMPPG 276_ HTRMP 281_ ENQRL 286_ ETLTK 291_ LLQSQ 296_ SQLLR 301_ ELVLL 306_ PAGAD 311_ SLRAQ 316_ SHRAE 321_ LDRKL 326_ VQVEE 331_ AIKIF 336_ SRPKV 341_FVKMD
1: Microtubule-binding protein which regulates microtubule organization and stability (PubMed:35072334, PubMed:35197565). Promotes the stability of astral microtubules and facilitates the proper orientation of the mitotic spindle (PubMed:35197565). This allows the oriented division of basal keratinocytes and contributes to epidermal stratification (By similarity). Required for the assembly of both primary and motile cilia (PubMed:35301795). Destabilizes the interaction between CCP110 and CEP97 by competing with CEP97 for binding to CCP110 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis (PubMed:35301795)