Protein mono-ADP-ribosyltransferase PARP12 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Poly [ADP-ribose] polymerase 12) (PARP-12) (Zinc finger CCCH domain-containing protein 1)
1_MAQAG 6_ VVGEV 11_ TQVLC 16_ AAGGA 21_ LELPE 26_ LRRRL 31_ RMGLS 36_ ADALE 41_ RLLRQ 46_ RGRFV 51_ VAVRA 56_ GGAAA 61_ APERV 66_ VLAAS 71_ PLRLC 76_ RAHQG 81_ SKPGC 86_ VGLCA 91_ QLHLC 96_ RFMVY 101_ GACKF 106_ LRAGK 111_ NCRNS 116_ HSLTT 121_ EHNLS 126_ VLRTH 131_ GVDHL 136_ SYNEL 141_ CQLLF 146_ QNDPW 151_ LLPEI 156_ CQHYN 161_ KGDGP 166_ HGSCA 171_ FQKQC 176_ IKLHI 181_ CQYFL 186_ QGECK 191_ FGTSC 196_ KRSHD 201_ FSNSE 206_ NLEKL 211_ EKLGM 216_ SSDLV 221_ SRLPT 226_ IYRNA 231_ HDIKN 236_ KSSAP 241_ SRVPP 246_ LFVPQ 251_ GTSER 256_ KDSSG 261_ SVSPN 266_ TLSQE 271_ EGDQI 276_ CLYHI 281_ RKSCS 286_ FQDKC 291_ HRVHF 296_ HLPYR 301_ WQFLD 306_ RGKWE 311_ DLDNM 316_ ELIEE 321_ AYCNP 326_ KIERI 331_ LCSES 336_ ASTFH 341_ SHCLN 346_ FNAMT 351_ YGATQ 356_ ARRLS 361_ TASSV 366_ TKPPH 371_ FILTT 376_ DWIWY 381_ WSDEF 386_ GSWQE 391_ YGRQG 396_ TVHPV 401_ TTVSS 406_ SDVEK 411_ AYLAY 416_ CTPGS 421_ DGQAA 426_ TLKFQ 431_ AGKHN 436_ YELDF 441_ KAFVQ 446_ KNLVY 451_ GTTKK 456_ VCRRP 461_ KYVSP 466_ QDVTT 471_ MQTCN 476_ TKFPG 481_ PKSIP 486_ DYWDS 491_ SALPD 496_ PGFQK 501_ ITLSS 506_ SSEEY 511_ QKVWN 516_ LFNRT 521_ LPFYF 526_ VQKIE 531_ RVQNL 536_ ALWEV 541_ YQWQK 546_ GQMQK 551_ QNGGK 556_ AVDER 561_ QLFHG 566_ TSAIF 571_ VDAIC 576_ QQNFD 581_ WRVCG 586_ VHGTS 591_ YGKGS 596_ YFARD 601_ AAYSH 606_ HYSKS 611_ DTQTH 616_ TMFLA 621_ RVLVG 626_ EFVRG 631_ NASFV 636_ RPPAK 641_ EGWSN 646_ AFYDS 651_ CVNSV 656_ SDPSI 661_ FVIFE 666_ KHQVY 671_ PEYVI 676_ QYTTS 681_ SKPSV 686_ TPSIL 691_ LALGS 696_LFSSR
1: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:34969853). Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication (PubMed:34187568). Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4 (PubMed:39888989). Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1 (PubMed:34969853). Acts also as a key regulator of mitochondrial function, protein translation, and inflammation. Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by upregulating ISG15 and ISGylation (PubMed:39465252)