Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)
1_MVMAD 6_ GPRHL 11_ QRGPV 16_ RVGFY 21_ DIEGT 26_ LGKGN 31_ FAVVK 36_ LGRHR 41_ ITKTE 46_ VAIKI 51_ IDKSQ 56_ LDAVN 61_ LEKIY 66_ REVQI 71_ MKMLD 76_ HPHII 81_ KLYQV 86_ METKS 91_ MLYLV 96_ TEYAK 101_ NGEIF 106_ DYLAN 111_ HGRLN 116_ ESEAR 121_ RKFWQ 126_ ILSAV 131_ DYCHG 136_ RKIVH 141_ RDLKA 146_ ENLLL 151_ DNNMN 156_ IKIAD 161_ FGFGN 166_ FFKSG 171_ ELLAT 176_ WCGSP 181_ PYAAP 186_ EVFEG 191_ QQYEG 196_ PQLDI 201_ WSMGV 206_ VLYVL 211_ VCGAL 216_ PFDGP 221_ TLPIL 226_ RQRVL 231_ EGRFR 236_ IPYFM 241_ SEDCE 246_ HLIRR 251_ MLVLD 256_ PSKRL 261_ TIAQI 266_ KEHKW 271_ MLIEV 276_ PVQRP 281_ VLYPQ 286_ EQENE 291_ PSIGE 296_ FNEQV 301_ LRLMH 306_ SLGID 311_ QQKTI 316_ ESLQN 321_ KSYNH 326_ FAAIY 331_ FLLVE 336_ RLKSH 341_ RSSFP 346_ VEQRL 351_ DGRQR 356_ RPSTI 361_ AEQTV 366_ AKAQT 371_ VGLPV 376_ TMHSP 381_ NMRLL 386_ RSALL 391_ PQASN 396_ VEAFS 401_ FPASG 406_ CQAEA 411_ AFMEE 416_ ECVDT 421_ PKVNG 426_ CLLDP 431_ VPPVL 436_ VRKGC 441_ QSLPS 446_ NMMET 451_ SIDEG 456_ LETEG 461_ EAEED 466_ PAHAF 471_ EAFQS 476_ TRSGQ 481_ RRHTL 486_ SEVTN 491_ QLVVM 496_ PGAGK 501_ IFSMN 506_ DSPSL 511_ DSVDS 516_ EYDMG 521_ SVQRD 526_ LNFLE 531_ DNPSL 536_ KDIML 541_ ANQPS 546_ PRMTS 551_ PFISL 556_ RPTNP 561_ AMQAL 566_ SSQKR 571_ EVHNR 576_ SPVSF 581_ REGRR 586_ ASDTS 591_ LTQGI 596_ VAFRQ 601_ HLQNL 606_ ARTKG 611_ ILELN 616_ KVQLL 621_ YEQIG 626_ PEADP 631_ NLAPA 636_ APQLQ 641_ DLASS 646_ CPQEE 651_ VSQQQ 656_ ESVST 661_ LPASV 666_ HPQLS 671_ PRQSL 676_ ETQYL 681_ QHRLQ 686_ KPSLL 691_ SKAQN 696_ TCQLY 701_ CKEPP 706_ RSLEQ 711_ QLQEH 716_ RLQQK 721_ RLFLQ 726_ KQSQL 731_ QAYFN 736_ QMQIA 741_ ESSYP 746_ QPSQQ 751_ LPLPR 756_ QETPP 761_ PSQQA 766_ PPFSL 771_ TQPLS 776_ PVLEP 781_ SSEQM 786_ QYSPF 791_ LSQYQ 796_ EMQLQ 801_ PLPST 806_ SGPRA 811_ APPLP 816_ TQLQQ 821_ QQPPP 826_ PPPPP 831_ PPRQP 836_ GAAPA 841_ PLQFS 846_ YQTCE 851_ LPSAA 856_ SPAPD 861_ YPTPC 866_ QYPVD 871_ GAQQS 876_ DLTGP 881_ DCPRS 886_ PGLQE 891_ APSSY 896_ DPLAL 901_ SELPG 906_ LFDCE 911_ MLDAV 916_ DPQHN 921_GYVLV
1: Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators (PubMed:15454081). Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity (PubMed:21084751, PubMed:26983400). In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL (PubMed:21084751, PubMed:26983400). Also plays a role in thymic T-cell development (By similarity)