NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
1_MATAS 6_ PRSDT 11_ SNNHS 16_ GRLQL 21_ QVTVS 26_ SAKLK 31_ RKKNW 36_ FGTAI 41_ YTEVV 46_ VDGEI 51_ TKTAK 56_ SSSSS 61_ NPKWD 66_ EQLTV 71_ NVTPQ 76_ TTLEF 81_ QVWSH 86_ RTLKA 91_ DALLG 96_ KATID 101_ LKQAL 106_ LIHNR 111_ KLERV 116_ KEQLK 121_ LSLEN 126_ KNGIA 131_ QTGEL 136_ TVVLD 141_ GLVIE 146_ QENIT 151_ NCSSS 156_ PTIEI 161_ QENGD 166_ ALHEN 171_ GEPSA 176_ RTTAR 181_ LAVEG 186_ TNGID 191_ NHVPT 196_ STLVQ 201_ NSCCS 206_ YVVNG 211_ DNTPS 216_ SPSQV 221_ AARPK 226_ NTPAP 231_ KPLAS 236_ EPADD 241_ TVNGE 246_ SSSFA 251_ PTDNA 256_ SVTGT 261_ PVVSE 266_ ENALS 271_ PNCTS 276_ TTVED 281_ PPVQE 286_ ILTSS 291_ ENNEC 296_ IPSTS 301_ AELES 306_ EARSI 311_ LEPDT 316_ SNSRS 321_ SSAFE 326_ AAKSR 331_ QPDGC 336_ MDPVR 341_ QQSGN 346_ ANTET 351_ LPSGW 356_ EQRKD 361_ PHGRT 366_ YYVDH 371_ NTRTT 376_ TWERP 381_ QPLPP 386_ GWERR 391_ VDDRR 396_ RVYYV 401_ DHNTR 406_ TTTWQ 411_ RPTME 416_ SVRNF 421_ EQWQS 426_ QRNQL 431_ QGAMQ 436_ QFNQR 441_ YLYSA 446_ SMLAA 451_ ENDPY 456_ GPLPP 461_ GWEKR 466_ VDSTD 471_ RVYFV 476_ NHNTK 481_ TTQWE 486_ DPRTQ 491_ GLQNE 496_ EPLPE 501_ GWEIR 506_ YTREG 511_ VRYFV 516_ DHNTR 521_ TTTFK 526_ DPRNG 531_ KSSVT 536_ KGGPQ 541_ IAYER 546_ GFRWK 551_ LAHFR 556_ YLCQS 561_ NALPS 566_ HVKIN 571_ VSRQT 576_ LFEDS 581_ FQQIM 586_ ALKPY 591_ DLRRR 596_ LYVIF 601_ RGEEG 606_ LDYGG 611_ LAREW 616_ FFLLS 621_ HEVLN 626_ PMYCL 631_ FEYAG 636_ KNNYC 641_ LQINP 646_ ASTIN 651_ PDHLS 656_ YFCFI 661_ GRFIA 666_ MALFH 671_ GKFID 676_ TGFSL 681_ PFYKR 686_ MLSKK 691_ LTIKD 696_ LESID 701_ TEFYN 706_ SLIWI 711_ RDNNI 716_ EECGL 721_ EMYFS 726_ VDMEI 731_ LGKVT 736_ SHDLK 741_ LGGSN 746_ ILVTE 751_ ENKDE 756_ YIGLM 761_ TEWRF 766_ SRGVQ 771_ EQTKA 776_ FLDGF 781_ NEVVP 786_ LQWLQ 791_ YFDEK 796_ ELEVM 801_ LCGMQ 806_ EVDLA 811_ DWQRN 816_ TVYRH 821_ YTRNS 826_ KQIIW 831_ FWQFV 836_ KETDN 841_ EVRMR 846_ LLQFV 851_ TGTCR 856_ LPLGG 861_ FAELM 866_ GSNGP 871_ QKFCI 876_ EKVGK 881_ DTWLP 886_ RSHTC 891_ FNRLD 896_ LPPYK 901_ SYEQL 906_ KEKLL 911_ FAIEE 916_TEGFG
1: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. Activates the Hippo signaling pathway in response to cell contact inhibition and recruitment to the Crumbs complex at the cell membrane (PubMed:34404733). Monoubiquitinates AMOTL2 which facilitates its interaction with and activation of LATS2 (PubMed:34404733). LATS2 then phosphorylates YAP1, excluding it from the nucleus and therefore ultimately represses YAP1-driven transcription of target genes (PubMed:34404733)