Ras-related protein Rab-6C (Rab6-like protein WTH3)
1_MSAGG 6_ DFGNP 11_ LRKFK 16_ LVFLG 21_ EQSVA 26_ KTSLI 31_ TRFRY 36_ DSFDN 41_ TYQAI 46_ IGIDF 51_ LSKTM 56_ YLEDG 61_ TIGLR 66_ LWDTA 71_ GQERL 76_ RSLIP 81_ RYIRD 86_ SAAAV 91_ VVYDI 96_ TNVNS 101_ FQQTT 106_ KWIDD 111_ VRTER 116_ GSDVI 121_ ITLVG 126_ NRTDL 131_ ADKRQ 136_ VSVEE 141_ GERKA 146_ KGLNV 151_ TFIET 156_ RAKAG 161_ YNVKQ 166_ LFRRV 171_ AAALP 176_ GMEST 181_ QDGSR 186_ EDMSD 191_ IKLEK 196_ PQEQT 201_ VSEGG 206_ CSCYS 211_ PMSSS 216_ TLPQK 221_ PPYSF 226_ IDCSV 231_ NIGLN 236_ LFPSL 241_ ITFCN 246_SSLLP
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB6C may be involved in the regulation of centrosome duplication and cell cycle progression