Gene name: PCBD2

Uniprot entry:

Q9H0N5

Protein names:

Pterin-4-alpha-carbinolamine dehydratase 2 (PHS 2) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase 2) (DcoH-like protein DCoHm) (Dimerization cofactor of hepatocyte nuclear factor 1 from muscle) (HNF-1-alpha dimerization cofactor)

Protein sequence:

1_MAAVL 6_ GALGA 11_ TRRLL 16_ AALRG 21_ QSLGL 26_ AAMSS 31_ GTHRL 36_ TAEER 41_ NQAIL 46_ DLKAA 51_ GWSEL 56_ SERDA 61_ IYKEF 66_ SFHNF 71_ NQAFG 76_ FMSRV 81_ ALQAE 86_ KMNHH 91_ PEWFN 96_ VYNKV 101_ QITLT 106_ SHDCG 111_ ELTKK 116_ DVKLA 121_KFIEK

Protein annotations

Protein functions:

1: Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity)

2: Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity