Guanylate-binding protein 3 (EC 3.6.5.-) (GTP-binding protein 3) (GBP-3) (Guanine nucleotide-binding protein 3)
1_MAPEI 6_ HMTGP 11_ MCLIE 16_ NTNGE 21_ LVANP 26_ EALKI 31_ LSAIT 36_ QPVVV 41_ VAIVG 46_ LYRTG 51_ KSYLM 56_ NKLAG 61_ KNKGF 66_ SLGST 71_ VKSHT 76_ KGIWM 81_ WCVPH 86_ PKKPE 91_ HTLVL 96_ LDTEG 101_ LGDVK 106_ KGDNQ 111_ NDSWI 116_ FTLAV 121_ LLSST 126_ LVYNS 131_ MGTIN 136_ QQAMD 141_ QLYYV 146_ TELTH 151_ RIRSK 156_ SSPDE 161_ NENED 166_ SADFV 171_ SFFPD 176_ FVWTL 181_ RDFSL 186_ DLEAD 191_ GQPLT 196_ PDEYL 201_ EYSLK 206_ LTQGT 211_ SQKDK 216_ NFNLP 221_ RLCIR 226_ KFFPK 231_ KKCFV 236_ FDLPI 241_ HRRKL 246_ AQLEK 251_ LQDEE 256_ LDPEF 261_ VQQVA 266_ DFCSY 271_ IFSNS 276_ KTKTL 281_ SGGIK 286_ VNGPR 291_ LESLV 296_ LTYIN 301_ AISRG 306_ DLPCM 311_ ENAVL 316_ ALAQI 321_ ENSAA 326_ VQKAI 331_ AHYDQ 336_ QMGQK 341_ VQLPA 346_ ETLQE 351_ LLDLH 356_ RVSER 361_ EATEV 366_ YMKNS 371_ FKDVD 376_ HLFQK 381_ KLAAQ 386_ LDKKR 391_ DDFCK 396_ QNQEA 401_ SSDRC 406_ SALLQ 411_ VIFSP 416_ LEEEV 421_ KAGIY 426_ SKPGG 431_ YCLFI 436_ QKLQD 441_ LEKKY 446_ YEEPR 451_ KGIQA 456_ EEILQ 461_ TYLKS 466_ KESVT 471_ DAILQ 476_ TDQIL 481_ TEKEK 486_ EIEVE 491_ CVKAE 496_ SAQAS 501_ AKMVE 506_ EMQIK 511_ YQQMM 516_ EEKEK 521_ SYQEH 526_ VKQLT 531_ EKMER 536_ ERAQL 541_ LEEQE 546_ KTLTS 551_ KLQEQ 556_ ARVLK 561_ ERCQG 566_ ESTQL 571_ QNEIQ 576_ KLQKT 581_ LKKKT 586_KRYMS
1: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:22106366). Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product (By similarity). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). Exhibits antiviral activity against influenza virus (PubMed:22106366)
2: Shows the most prominent antiviral activity in epithelial cells