Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1)
1_MKFQY 6_ KEDHP 11_ FEYRK 16_ KEGEK 21_ IRKKY 26_ PDRVP 31_ VIVEK 36_ APKAR 41_ VPDLD 46_ KRKYL 51_ VPSDL 56_ TVGQF 61_ YFLIR 66_ KRIHL 71_ RPEDA 76_ LFFFV 81_ NNTIP 86_ PTSAT 91_ MGQLY 96_ EDNHE 101_ EDYFL 106_ YVAYS 111_DESVY
1: Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor (PubMed:16431922). Involved in formation of autophagosomal vacuoles (PubMed:20404487). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20404487). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538)