Ras-related protein Rab-17
1_MAQAH 6_ RTPQP 11_ RAAPS 16_ QPRVF 21_ KLVLL 26_ GSGSV 31_ GKSSL 36_ ALRYV 41_ KNDFK 46_ SILPT 51_ VGCAF 56_ FTKVV 61_ DVGAT 66_ SLKLE 71_ IWDTA 76_ GQEKY 81_ HSVCH 86_ LYFRG 91_ ANAAL 96_ LVYDI 101_ TRKDS 106_ FLKAQ 111_ QWLKD 116_ LEEEL 121_ HPGEV 126_ LVMLV 131_ GNKTD 136_ LSQER 141_ EVTFQ 146_ EGKEF 151_ ADSQK 156_ LLFME 161_ TSAKL 166_ NHQVS 171_ EVFNT 176_ VAQEL 181_ LQRSD 186_ EEGQA 191_ LRGDA 196_ AVALN 201_ KGPAR 206_QAKCC
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB17 is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration (PubMed:22328529)