Ras-related protein Rab-1B (EC 3.6.5.2)
1_MNPEY 6_ DYLFK 11_ LLLIG 16_ DSGVG 21_ KSCLL 26_ LRFAD 31_ DTYTE 36_ SYIST 41_ IGVDF 46_ KIRTI 51_ ELDGK 56_ TIKLQ 61_ IWDTA 66_ GQERF 71_ RTITS 76_ SYYRG 81_ AHGII 86_ VVYDV 91_ TDQES 96_ YANVK 101_ QWLQE 106_ IDRYA 111_ SENVN 116_ KLLVG 121_ NKSDL 126_ TTKKV 131_ VDNTT 136_ AKEFA 141_ DSLGI 146_ PFLET 151_ SAKNA 156_ TNVEQ 161_ AFMTM 166_ AAEIK 171_ KRMGP 176_ GAASG 181_ GERPN 186_ LKIDS 191_ TPVKP 196_AGGGC
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20545908, PubMed:9437002, PubMed:23236136). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Required to modulate the compacted morphology of the Golgi (PubMed:26209634). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity)