Coiled-coil domain-containing protein 8
1_MLQIG 6_ EDVDY 11_ LLIPR 16_ EVRLA 21_ GGVWR 26_ VISKP 31_ ATKEA 36_ EFRER 41_ LTQFL 46_ EEEGR 51_ TLEDV 56_ ARIME 61_ KSTPH 66_ PPQPP 71_ KKPKE 76_ PRVRR 81_ RVQQM 86_ VTPPP 91_ RLVVG 96_ TYDSS 101_ NASDS 106_ EFSDF 111_ ETSRD 116_ KSRQG 121_ PRRGK 126_ KVRKM 131_ PVSYL 136_ GSKFL 141_ GSDLE 146_ SEDDE 151_ ELVEA 156_ FLRRQ 161_ EKQPS 166_ APPAR 171_ RRVNL 176_ PVPMF 181_ EDNLG 186_ PQLSK 191_ ADRWR 196_ EYVSQ 201_ VSWGK 206_ LKRRV 211_ KGWAP 216_ RAGPG 221_ VGEAR 226_ LASTA 231_ VESAG 236_ VSSAP 241_ EGTSP 246_ GDRLG 251_ NAGDV 256_ CVPQA 261_ SPRRW 266_ RPKIN 271_ WASFR 276_ RRRKE 281_ QTAPT 286_ GQGAD 291_ IEADQ 296_ GGEAA 301_ DSQRE 306_ EAIAD 311_ QREGA 316_ AGNQR 321_ AGAPA 326_ DQGAE 331_ AADNQ 336_ REEAA 341_ DNQRA 346_ GAPAE 351_ EGAEA 356_ ADNQR 361_ EEAAD 366_ NQRAE 371_ APADQ 376_ RSQGT 381_ DNHRE 386_ EAADN 391_ QRAEA 396_ PADQG 401_ SEVTD 406_ NQREE 411_ AVHDQ 416_ RERAP 421_ AVQGA 426_ DNQRA 431_ QARAG 436_ QRAEA 441_ AHNQR 446_ AGAPG 451_ IQEAE 456_ VSAAQ 461_ GTTGT 466_ APGAR 471_ ARKQV 476_ KTVRF 481_ QTPGR 486_ FSWFC 491_ KRRRA 496_ FWHTP 501_ RLPTL 506_ PKRVP 511_ RAGEA 516_ RNLRV 521_ LRAEA 526_ RAEAE 531_QGEQE
1: Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Required for localization of CUL7 to the centrosome (PubMed:24793695)