Oxysterol-binding protein-related protein 5 (ORP-5) (OSBP-related protein 5) (Oxysterol-binding protein homolog 1)
1_MKEEA 6_ FLRRR 11_ FSLCP 16_ PSSTP 21_ QKVDP 26_ RKLTR 31_ NLLLS 36_ GDNEL 41_ YPLSP 46_ GKDME 51_ PNGPS 56_ LPRDE 61_ GPPTP 66_ SSATK 71_ VPPAE 76_ YRLCN 81_ GSDKE 86_ CVSPT 91_ ARVTK 96_ KETLK 101_ AQKEN 106_ YRQEK 111_ KRATR 116_ QLLSA 121_ LTDPS 126_ VVIMA 131_ DSLKI 136_ RGTLK 141_ SWTKL 146_ WCVLK 151_ PGVLL 156_ IYKTP 161_ KVGQW 166_ VGTVL 171_ LHCCE 176_ LIERP 181_ SKKDG 186_ FCFKL 191_ FHPLD 196_ QSVWA 201_ VKGPK 206_ GESVG 211_ SITQP 216_ LPSSY 221_ LIFRA 226_ ASESD 231_ GRCWL 236_ DALEL 241_ ALRCS 246_ SLLRL 251_ GTCKP 256_ GRDGE 261_ PGTSP 266_ DASPS 271_ SLCGL 276_ PASAT 281_ VHPDQ 286_ DLFPL 291_ NGSSL 296_ ENDAF 301_ SDKSE 306_ RENPE 311_ ESDTE 316_ TQDHS 321_ RKTES 326_ GSDQS 331_ ETPGA 336_ PVRRG 341_ TTYVE 346_ QVQEE 351_ LGELG 356_ EASQV 361_ ETVSE 366_ ENKSL 371_ MWTLL 376_ KQLRP 381_ GMDLS 386_ RVVLP 391_ TFVLE 396_ PRSFL 401_ NKLSD 406_ YYYHA 411_ DLLSR 416_ AAVEE 421_ DAYSR 426_ MKLVL 431_ RWYLS 436_ GFYKK 441_ PKGIK 446_ KPYNP 451_ ILGET 456_ FRCCW 461_ FHPQT 466_ DSRTF 471_ YIAEQ 476_ VSHHP 481_ PVSAF 486_ HVSNR 491_ KDGFC 496_ ISGSI 501_ TAKSR 506_ FYGNS 511_ LSALL 516_ DGKAT 521_ LTFLN 526_ RAEDY 531_ TLTMP 536_ YAHCK 541_ GILYG 546_ TMTLE 551_ LGGKV 556_ TIECA 561_ KNNFQ 566_ AQLEF 571_ KLKPF 576_ FGGST 581_ SINQI 586_ SGKIT 591_ SGEEV 596_ LASLS 601_ GHWDR 606_ DVFIK 611_ EEGSG 616_ SSALF 621_ WTPSG 626_ EVRRQ 631_ RLRQH 636_ TVPLE 641_ EQTEL 646_ ESERL 651_ WQHVT 656_ RAISK 661_ GDQHR 666_ ATQEK 671_ FALEE 676_ AQRQR 681_ ARERQ 686_ ESLMP 691_ WKPQL 696_ FHLDP 701_ ITQEW 706_ HYRYE 711_ DHSPW 716_ DPLKD 721_ IAQFE 726_ QDGIL 731_ RTLQQ 736_ EAVAR 741_ QTTFL 746_ GSPGP 751_ RHERS 756_ GPDQR 761_ LRKAS 766_ DQPSG 771_ HSQAT 776_ ESSGS 781_ TPESC 786_ PELSD 791_ EEQDG 796_ DFVPG 801_ GESPC 806_ PRCRK 811_ EARRL 816_ QALHE 821_ AILSI 826_ REAQQ 831_ ELHRH 836_ LSAML 841_ SSTAR 846_ AAQAP 851_ TPGLL 856_ QSPRS 861_ WFLLC 866_ VFLAC 871_QLFIN
1: Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193)