RNA-binding protein 38 (CLL-associated antigen KW-5) (HSRNASEB) (RNA-binding motif protein 38) (RNA-binding region-containing protein 1) (ssDNA-binding protein SEB4)
1_MLLQP 6_ APCAP 11_ SAGFP 16_ RPLAA 21_ PGAMH 26_ GSQKD 31_ TTFTK 36_ IFVGG 41_ LPYHT 46_ TDASL 51_ RKYFE 56_ GFGDI 61_ EEAVV 66_ ITDRQ 71_ TGKSR 76_ GYGFV 81_ TMADR 86_ AAAER 91_ ACKDP 96_ NPIID 101_ GRKAN 106_ VNLAY 111_ LGAKP 116_ RSLQT 121_ GFAIG 126_ VQQLH 131_ PTLIQ 136_ RTYGL 141_ TPHYI 146_ YPPAI 151_ VQPSV 156_ VIPAA 161_ PVPSL 166_ SSPYI 171_ EYTPA 176_ SPAYA 181_ QYPPA 186_ TYDQY 191_ PYAAS 196_ PATAA 201_ SFVGY 206_ SYPAA 211_ VPQAL 216_ SAAAP 221_ AGTTF 226_ VQYQA 231_PQLQP
1: RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation
2: (Microbial infection) Essential factor for the splicing of the pre-mRNAs of human parvovirus B19 (B19V) and for the expression of B19V 11-kDa protein, which enhances viral replication