Inhibitor of growth protein 2 (Inhibitor of growth 1-like protein) (ING1Lp) (p32) (p33ING2)
1_MLGQQ 6_ QQQLY 11_ SSAAL 16_ LTGER 21_ SRLLT 26_ CYVQD 31_ YLECV 36_ ESLPH 41_ DMQRN 46_ VSVLR 51_ ELDNK 56_ YQETL 61_ KEIDD 66_ VYEKY 71_ KKEDD 76_ LNQKK 81_ RLQQL 86_ LQRAL 91_ INSQE 96_ LGDEK 101_ IQIVT 106_ QMLEL 111_ VENRA 116_ RQMEL 121_ HSQCF 126_ QDPAE 131_ SERAS 136_ DKAKM 141_ DSSQP 146_ ERSSR 151_ RPRRQ 156_ RTSES 161_ RDLCH 166_ MANGI 171_ EDCDD 176_ QPPKE 181_ KKSKS 186_ AKKKK 191_ RSKAK 196_ QEREA 201_ SPVEF 206_ AIDPN 211_ EPTYC 216_ LCNQV 221_ SYGEM 226_ IGCDN 231_ EQCPI 236_ EWFHF 241_ SCVSL 246_ TYKPK 251_ GKWYC 256_ PKCRG 261_ DNEKT 266_ MDKST 271_EKTKK
1: Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs)