Protein-L-histidine N-pros-methyltransferase (EC 2.1.1.-) (DORA reverse strand protein) (DREV) (DREV1) (Methyltransferase-like protein 9) (hMETTL9)
1_MRLLA 6_ GWLCL 11_ SLASV 16_ WLARR 21_ MWTLR 26_ SPLTR 31_ SLYVN 36_ MTSGP 41_ GGPAA 46_ AAGGR 51_ KENHQ 56_ WYVCN 61_ REKLC 66_ ESLQA 71_ VFVQS 76_ YLDQG 81_ TQIFL 86_ NNSIE 91_ KSGWL 96_ FIQLY 101_ HSFVS 106_ SVFSL 111_ FMSRT 116_ SINGL 121_ LGRGS 126_ MFVFS 131_ PDQFQ 136_ RLLKI 141_ NPDWK 146_ THRLL 151_ DLGAG 156_ DGEVT 161_ KIMSP 166_ HFEEI 171_ YATEL 176_ SETMI 181_ WQLQK 186_ KKYRV 191_ LGINE 196_ WQNTG 201_ FQYDV 206_ ISCLN 211_ LLDRC 216_ DQPLT 221_ LLKDI 226_ RSVLE 231_ PTRGR 236_ VILAL 241_ VLPFH 246_ PYVEN 251_ VGGKW 256_ EKPSE 261_ ILEIK 266_ GQNWE 271_ EQVNS 276_ LPEVF 281_ RKAGF 286_ VIEAF 291_ TRLPY 296_ LCEGD 301_ MYNDY 306_ YVLDD 311_AVFVL
1: Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins (PubMed:33563959, PubMed:34562450, PubMed:37015930, PubMed:37398635). Specifically methylates the second His of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid), while exploiting the first one as a recognition signature (PubMed:37398635). Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins (PubMed:33563959, PubMed:34562450, PubMed:37015930, PubMed:37398635). Constitutes the main methyltransferase for the 1-methylhistidine modification in cell (PubMed:33563959)