Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like)
1_MSAAQ 6_ VSSSR 11_ RQSCY 16_ LCDLP 21_ RMPWA 26_ MIWDF 31_ SEPVC 36_ RGCVN 41_ YEGAD 46_ RIEFV 51_ IETAR 56_ QLKRA 61_ HGCFQ 66_ DGRSP 71_ GPPPP 76_ VGVKT 81_ VALSA 86_ KEAAA 91_ AAAAA 96_ AAAAA 101_ AAQQQ 106_ QQQQQ 111_ QQQQQ 116_ QQQQQ 121_ QQQQQ 126_ QQLNH 131_ VDGSS 136_ KPAVL 141_ AAPSG 146_ LERYG 151_ LSAAA 156_ AAAAA 161_ AAAAV 166_ EQRSR 171_ FEYPP 176_ PPVSL 181_ GSSSH 186_ TARLP 191_ NGLGG 196_ PNGFP 201_ KPTPE 206_ EGPPE 211_ LNRQS 216_ PNSSS 221_ AAASV 226_ ASRRG 231_ THGGL 236_ VTGLP 241_ NPGGG 246_ GGPQL 251_ TVPPN 256_ LLPQT 261_ LLNGP 266_ ASAAV 271_ LPPPP 276_ PHALG 281_ SRGPP 286_ TPAPP 291_ GAPGG 296_ PACLG 301_ GTPGV 306_ SATSS 311_ SASSS 316_ TSSSV 321_ AEVGV 326_ GAGGK 331_ RPGSV 336_ SSTDQ 341_ ERELK 346_ EKQRN 351_ AEALA 356_ ELSES 361_ LRNRA 366_ EEWAS 371_ KPKMV 376_ RDTLL 381_ TLAGC 386_ TPYEV 391_ RFKKD 396_ HSLLG 401_ RVFAF 406_ DAVSK 411_ PGMDY 416_ ELKLF 421_ IEYPT 426_ GSGNV 431_ YSSAS 436_ GVAKQ 441_ MYQDC 446_ MKDFG 451_ RGLSS 456_ GFKYL 461_ EYEKK 466_ HGSGD 471_ WRLLG 476_ DLLPE 481_ AVRFF 486_ KEGVP 491_ GADML 496_ PQPYL 501_ DASCP 506_ MLPTA 511_ LVSLS 516_ RAPSA 521_ PPGTG 526_ ALPPA 531_ APSGR 536_ GAAAS 541_ LRKRK 546_ ASPEP 551_ PDSAE 556_ GALKL 561_ GEEQQ 566_ RQQWM 571_ ANQSE 576_ ALKLT 581_ MSAGG 586_ FAAPG 591_ HAAGG 596_ PPPPP 601_ PPLGP 606_ HSNRT 611_ TPPES 616_ APQNG 621_ PSPMA 626_ ALMSV 631_ ADTLG 636_ TAHSP 641_ KDGSS 646_ VHSTT 651_ ASARR 656_ NSSSP 661_ VSPAS 666_ VPGQR 671_ RLASR 676_ NGDLN 681_ LQVAP 686_ PPPSA 691_ HPGMD 696_ QVHPQ 701_ NIPDS 706_ PMANS 711_ GPLCC 716_ TICHE 721_ RLEDT 726_ HFVQC 731_ PSVPS 736_ HKFCF 741_ PCSRE 746_ SIKAQ 751_ GATGE 756_ VYCPS 761_ GEKCP 766_ LVGSN 771_ VPWAF 776_ MQGEI 781_ ATILA 786_ GDVKV 791_KKERD
1: Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity)