Protein unc-93 homolog B1 (Unc-93B1) (hUNC93B1)
1_MEAEP 6_ PLYPM 11_ AGAAG 16_ PQGDE 21_ DLLGV 26_ PDGPE 31_ APLDE 36_ LVGAY 41_ PNYNE 46_ EEEER 51_ RYYRR 56_ KRLGV 61_ LKNVL 66_ AASAG 71_ GMLTY 76_ GVYLG 81_ LLQMQ 86_ LILHY 91_ DETYR 96_ EVKYG 101_ NMGLP 106_ DIDSK 111_ MLMGI 116_ NVTPI 121_ AALLY 126_ TPVLI 131_ RFFGT 136_ KWMMF 141_ LAVGI 146_ YALFV 151_ STNYW 156_ ERYYT 161_ LVPSA 166_ VALGM 171_ AIVPL 176_ WASMG 181_ NYITR 186_ MAQKY 191_ HEYSH 196_ YKEQD 201_ GQGMK 206_ QRPPR 211_ GSHAP 216_ YLLVF 221_ QAIFY 226_ SFFHL 231_ SFACA 236_ QLPMI 241_ YFLNH 246_ YLYDL 251_ NHTLY 256_ NVQSC 261_ GTNSH 266_ GILSG 271_ FNKTV 276_ LRTLP 281_ RSGNL 286_ IVVES 291_ VLMAV 296_ AFLAM 301_ LLVLG 306_ LCGAA 311_ YRPTE 316_ EIDLR 321_ SVGWG 326_ NIFQL 331_ PFKHV 336_ RDYRL 341_ RHLVP 346_ FFIYS 351_ GFEVL 356_ FACTG 361_ IALGY 366_ GVCSV 371_ GLERL 376_ AYLLV 381_ AYSLG 386_ ASAAS 391_ LLGLL 396_ GLWLP 401_ RPVPL 406_ VAGAG 411_ VHLLL 416_ TFILF 421_ FWAPV 426_ PRVLQ 431_ HSWIL 436_ YVAAA 441_ LWGVG 446_ SALNK 451_ TGLST 456_ LLGIL 461_ YEDKE 466_ RQDFI 471_ FTIYH 476_ WWQAV 481_ AIFTV 486_ YLGSS 491_ LHMKA 496_ KLAVL 501_ LVTLV 506_ AAAVS 511_ YLRME 516_ QKLRR 521_ GVAPR 526_ QPRIP 531_ RPQHK 536_ VRGYR 541_ YLEED 546_ NSDES 551_ DAEGE 556_ HGDGA 561_ EEEAP 566_ PAGPR 571_ PGPEP 576_ AGLGR 581_ RPCPY 586_ EQAQG 591_GDGPE
1: Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal