Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2)
1_MGPLQ 6_ GDGGP 11_ ALGGA 16_ DVAPR 21_ LSPVR 26_ VWPRP 31_ QAPKE 36_ PALHP 41_ MGLSL 46_ PKEKG 51_ LILCL 56_ WSKFC 61_ RWFQR 66_ RESWA 71_ QSRDE 76_ QNLLQ 81_ QKRIW 86_ ESPLL 91_ LAAKD 96_ NDVQA 101_ LNKLL 106_ KYEDC 111_ KVHQR 116_ GAMGE 121_ TALHI 126_ AALYD 131_ NLEAA 136_ MVLME 141_ AAPEL 146_ VFEPM 151_ TSELY 156_ EGQTA 161_ LHIAV 166_ VNQNM 171_ NLVRA 176_ LLARR 181_ ASVSA 186_ RATGT 191_ AFRRS 196_ PCNLI 201_ YFGEH 206_ PLSFA 211_ ACVNS 216_ EEIVR 221_ LLIEH 226_ GADIR 231_ AQDSL 236_ GNTVL 241_ HILIL 246_ QPNKT 251_ FACQM 256_ YNLLL 261_ SYDRH 266_ GDHLQ 271_ PLDLV 276_ PNHQG 281_ LTPFK 286_ LAGVE 291_ GNTVM 296_ FQHLM 301_ QKRKH 306_ TQWTY 311_ GPLTS 316_ TLYDL 321_ TEIDS 326_ SGDEQ 331_ SLLEL 336_ IITTK 341_ KREAR 346_ QILDQ 351_ TPVKE 356_ LVSLK 361_ WKRYG 366_ RPYFC 371_ MLGAI 376_ YLLYI 381_ ICFTM 386_ CCIYR 391_ PLKPR 396_ TNNRT 401_ SPRDN 406_ TLLQQ 411_ KLLQE 416_ AYMTP 421_ KDDIR 426_ LVGEL 431_ VTVIG 436_ AIIIL 441_ LVEVP 446_ DIFRM 451_ GVTRF 456_ FGQTI 461_ LGGPF 466_ HVLII 471_ TYAFM 476_ VLVTM 481_ VMRLI 486_ SASGE 491_ VVPMS 496_ FALVL 501_ GWCNV 506_ MYFAR 511_ GFQML 516_ GPFTI 521_ MIQKM 526_ IFGDL 531_ MRFCW 536_ LMAVV 541_ ILGFA 546_ SAFYI 551_ IFQTE 556_ DPEEL 561_ GHFYD 566_ YPMAL 571_ FSTFE 576_ LFLTI 581_ IDGPA 586_ NYNVD 591_ LPFMY 596_ SITYA 601_ AFAII 606_ ATLLM 611_ LNLLI 616_ AMMGD 621_ THWRV 626_ AHERD 631_ ELWRA 636_ QIVAT 641_ TVMLE 646_ RKLPR 651_ CLWPR 656_ SGICG 661_ REYGL 666_ GDRWF 671_ LRVED 676_ RQDLN 681_ RQRIQ 686_ RYAQA 691_ FHTRG 696_ SEDLD 701_ KDSVE 706_ KLELG 711_ CPFSP 716_ HLSLP 721_ MPSVS 726_ RSTSR 731_ SSANW 736_ ERLRQ 741_ GTLRR 746_ DLRGI 751_ INRGL 756_EDGES
1: Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11248124, PubMed:11278579, PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating