DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6) (DNA-directed RNA polymerase III subunit F) (RNA polymerase III 39 kDa subunit) (RPC39)
1_MAEVK 6_ VKVQP 11_ PDADP 16_ VEIEN 21_ RIIEL 26_ CHQFP 31_ HGITD 36_ QVIQN 41_ EMPHI 46_ EAQQR 51_ AVAIN 56_ RLLSM 61_ GQLDL 66_ LRSNT 71_ GLLYR 76_ IKDSQ 81_ NAGKM 86_ KGSDN 91_ QEKLV 96_ YQIIE 101_ DAGNK 106_ GIWSR 111_ DIRYK 116_ SNLPL 121_ TEINK 126_ ILKNL 131_ ESKKL 136_ IKAVK 141_ SVAAS 146_ KKKVY 151_ MLYNL 156_ QPDRS 161_ VTGGA 166_ WYSDQ 171_ DFESE 176_ FVEVL 181_ NQQCF 186_ KFLQS 191_ KAETA 196_ RESKQ 201_ NPMIQ 206_ RNSSF 211_ ASSHE 216_ VWKYI 221_ CELGI 226_ SKVEL 231_ SMEDI 236_ ETILN 241_ TLIYD 246_ GKVEM 251_ TIIAA 256_ KEGTV 261_ GSVDG 266_ HMKLY 271_ RAVNP 276_ IIPPT 281_ GLVRA 286_ PCGLC 291_ PVFDD 296_ CHEGG 301_ EISPS 306_ NCIYM 311_TEWLE
1: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:21358628, PubMed:33558764, PubMed:34675218). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer that coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state (PubMed:20413673, PubMed:33558764, PubMed:33558766). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, including varicella zoster virus. Acts as a nuclear and cytosolic DNA sensor detecting AT-rich DNA, involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370, PubMed:30211253). Preferentially binds double-stranded DNA (dsDNA) (PubMed:21358628)