Ribonuclease 7 (RNase 7) (EC 3.1.27.-) (Skin-derived antimicrobial protein 2) (SAP-2)
1_MAPAR 6_ AGFCP 11_ LLLLL 16_ LLGLW 21_ VAEIP 26_ VSAKP 31_ KGMTS 36_ SQWFK 41_ IQHMQ 46_ PSPQA 51_ CNSAM 56_ KNINK 61_ HTKRC 66_ KDLNT 71_ FLHEP 76_ FSSVA 81_ ATCQT 86_ PKIAC 91_ KNGDK 96_ NCHQS 101_ HGAVS 106_ LTMCK 111_ LTSGK 116_ HPNCR 121_ YKEKR 126_ QNKSY 131_ VVACK 136_ PPQKK 141_ DSQQF 146_ HLVPV 151_HLDRV
1: Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966). Has broad-spectrum antimicrobial activity against many pathogenic microorganisms including uropathogenic E.coli (UPEC), and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium (PubMed:12244054, PubMed:12527768, PubMed:17150966, PubMed:25075772, PubMed:33818125). Causes loss of bacterial membrane integrity (PubMed:17150966). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:17150966)