Activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100) (Trip4 complex subunit p100)
1_MPALP 6_ LDQLQ 11_ ITHKD 16_ PKTGK 21_ LRTSP 26_ ALHPE 31_ QKADR 36_ YFVLY 41_ KPPPK 46_ DNIPA 51_ LVEEY 56_ LERAT 61_ FVAND 66_ LDWLL 71_ ALPHD 76_ KFWCQ 81_ VIFDE 86_ TLQKC 91_ LDSYL 96_ RYVPR 101_ KFDEG 106_ VASAP 111_ EVVDM 116_ QKRLH 121_ RSVFL 126_ TFLRM 131_ STHKE 136_ SKDHF 141_ ISPSA 146_ FGEIL 151_ YNNFL 156_ FDIPK 161_ ILDLC 166_ VLFGK 171_ GNSPL 176_ LQKMI 181_ GNIFT 186_ QQPSY 191_ YSDLD 196_ ETLPT 201_ ILQVF 206_ SNILQ 211_ HCGLQ 216_ GDGAN 221_ TTPQK 226_ LEERG 231_ RLTPS 236_ DMPLL 241_ ELKDI 246_ VLYLC 251_ DTCTT 256_ LWAFL 261_ DIFPL 266_ ACQTF 271_ QKHDF 276_ CYRLA 281_ SFYEA 286_ AIPEM 291_ ESAIK 296_ KRRLE 301_ DSKLL 306_ GDLWQ 311_ RLSHS 316_ RKKLM 321_ EIFHI 326_ ILNQI 331_ CLLPI 336_ LESSC 341_ DNIQG 346_ FIEEF 351_ LQIFS 356_ SLLQE 361_ KRFLR 366_ DYDAL 371_ FPVAE 376_ DISLL 381_ QQASS 386_ VLDET 391_ RTAYI 396_ LQAVE 401_ SAWEG 406_ VDRRK 411_ ATDAK 416_ DPSVI 421_ EEPNG 426_ EPNGV 431_ TVTAE 436_ AVSQA 441_ SSHPE 446_ NSEEE 451_ ECMGA 456_ AAAVG 461_ PAMCG 466_ VELDS 471_ LISQV 476_ KDLLP 481_ DLGEG 486_ FILAC 491_ LEYYH 496_ YDPEQ 501_ VINNI 506_ LEERL 511_ APTLS 516_ QLDRN 521_ LDREM 526_ KPDPT 531_ PLLTS 536_ RHNVF 541_ QNDEF 546_ DVFSR 551_ DSVDL 556_ SRVHK 561_ GKSTR 566_ KEENT 571_ RSLLN 576_ DKRAV 581_ AAQRQ 586_ RYEQY 591_ SVVVE 596_ EVPLQ 601_ PGESL 606_ PYHSV 611_ YYEDE 616_ YDDTY 621_ DGNQV 626_ GANDA 631_ DSDDE 636_ LISRR 641_ PFTIP 646_ QVLRT 651_ KVPRE 656_ GQEED 661_ DDDEE 666_ DDADE 671_ EAPKP 676_ DHFVQ 681_ DPAVL 686_ REKAE 691_ ARRMA 696_ FLAKK 701_ GYRHD 706_ SSTAV 711_ AGSPR 716_ GHGQS 721_ RETTQ 726_ ERRKK 731_ EANKA 736_ TRANH 741_ NRRTM 746_ ADRKR 751_SKGMI
1: Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes (PubMed:29144457, PubMed:32099016, PubMed:32579943, PubMed:36302773). Plays a role in DNA damage repair as component of the ASCC complex (PubMed:29144457). Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:32099016, PubMed:32579943, PubMed:36302773). Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:36302773)