Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3)
1_MRSEK 6_ EGAGG 11_ LRAAV 16_ AARGP 21_ SGREK 26_ LSALE 31_ VQFHR 36_ DSQQQ 41_ EAETP 46_ PTSSS 51_ GCGGG 56_ AGKPR 61_ EEKRT 66_ ALSKV 71_ VIRRL 76_ PPGLT 81_ KEQLE 86_ EQLRP 91_ LPAHD 96_ YFEFF 101_ AADLS 106_ LYPHL 111_ YSRAY 116_ INFRN 121_ PDDIL 126_ LFRDR 131_ FDGYI 136_ FLDSK 141_ GLEYP 146_ AVVEF 151_ APFQK 156_ IAKKK 161_ LRKKD 166_ AKTGS 171_ IEDDP 176_ EYKKF 181_ LETYC 186_ VEEEK 191_ TSANP 196_ ETLLG 201_ EMEAK 206_ TRELI 211_ ARRTT 216_ PLLEY 221_ IKNRK 226_ LEKQR 231_ IREEK 236_ REERR 241_ RRELE 246_ KKRLR 251_ EEEKR 256_ RRREE 261_ ERCKK 266_ KETDK 271_ QKKIA 276_ EKEVR 281_ IKLLK 286_ KPEKG 291_ EEPTT 296_ EKPKE 301_ RGEEI 306_ DTGGG 311_ KQESC 316_ APGAV 321_ VKARP 326_ MEGSL 331_ EEPQE 336_ TSHSG 341_ SDKEH 346_ RDVER 351_ SQEQE 356_ SEAQR 361_ YHVDD 366_ GRRHR 371_ AHHEP 376_ ERLSR 381_ RSEDE 386_ QRWGK 391_ GPGQD 396_ RGKKG 401_ SQDSG 406_ APGEA 411_ MERLG 416_ RAQRC 421_ DDSPA 426_ PRKER 431_ LANKD 436_ RPALQ 441_ LYDPG 446_ ARFRA 451_ RECGG 456_ NRRIC 461_ KAEGS 466_ GTGPE 471_KREEA
1: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation