Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20)
1_MASLD 6_ DPGEV 11_ REGFL 16_ CPLCL 21_ KDLQS 26_ FYQLH 31_ SHYEE 36_ EHSGE 41_ DRDVK 46_ GQIKS 51_ LVQKA 56_ KKAKD 61_ RLLKR 66_ EGDDR 71_ AESGT 76_ QGYES 81_ FSYGG 86_ VDPYM 91_ WEPQE 96_ LGAVR 101_ SHLSD 106_ FKKHR 111_ AARID 116_ HYVVE 121_ VNKLI 126_ IRLEK 131_ LTAFD 136_ RTNTE 141_ SAKIR 146_ AIEKS 151_ VVPWV 156_ NDQDV 161_ PFCPD 166_ CGNKF 171_ SIRNR 176_ RHHCR 181_ LCGSI 186_ MCKKC 191_ MELIS 196_ LPLAN 201_ KLTSA 206_ SKESL 211_ STHTS 216_ PSQSP 221_ NSVHG 226_ SRRGS 231_ ISSMS 236_ SVSSV 241_ LDEKD 246_ DDRIR 251_ CCTHC 256_ KDTLL 261_ KREQQ 266_ IDEKE 271_ HTPDI 276_ VKLYE 281_ KLRLC 286_ MEKVD 291_ QKAPE 296_ YIRMA 301_ ASLNA 306_ GETTY 311_ SLEHA 316_ SDLRV 321_ EVQKV 326_ YELID 331_ ALSKK 336_ ILTLG 341_ LNQDP 346_ PPHPS 351_ NLRLQ 356_ RMIRY 361_ SATLF 366_ VQEKL 371_ LGLMS 376_ LPTKE 381_ QFEEL 386_ KKKRK 391_ EEMER 396_ KRAVE 401_ RQAAL 406_ ESQRR 411_ LEERQ 416_ SGLAS 421_ RAANG 426_ EVASL 431_ RRGPA 436_ PLRKA 441_ EGWLP 446_ LSGGQ 451_ GQSED 456_ SDPLL 461_ QQIHN 466_ ITSFI 471_ RQAKA 476_ AGRMD 481_ EVRTL 486_ QENLR 491_ QLQDE 496_ YDQQQ 501_ TEKAI 506_ ELSRR 511_ QAEEE 516_ DLQRE 521_ QLQML 526_ REREL 531_ ERERE 536_ QFRVA 541_ SLHTR 546_ TRSLD 551_ FREIG 556_ PFQLE 561_ PSREP 566_ RTHLA 571_ YALDL 576_ GSSPV 581_ PSSTA 586_ PKTPS 591_ LSSTQ 596_ PTRVW 601_ SGPPA 606_ VGQER 611_ LPQSS 616_ MPQQH 621_ EGPSL 626_ NPFDE 631_ EDLSS 636_ PMEEA 641_ TTGPP 646_ AAGVS 651_ LDPSA 656_ RILKE 661_ YNPFE 666_ EEDEE 671_ EEAVA 676_ GNPFI 681_ QPDSP 686_ APNPF 691_ SEEDE 696_ HPQQR 701_ LSSPL 706_ VPGNP 711_ FEEPT 716_ CINPF 721_ EMDSD 726_ SGPEA 731_ EEPIE 736_ EELLL 741_ QQIDN 746_ IKAYI 751_ FDAKQ 756_ CGRLD 761_ EVEVL 766_ TENLR 771_ ELKHT 776_LAKQK
1: Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713). Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388)