Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2)
1_MNGEE 6_ EFFDA 11_ VTGFD 16_ SDNSS 21_ GEFSE 26_ ANQKV 31_ TGMID 36_ LDTSK 41_ NNRIG 46_ KTGER 51_ PSQEN 56_ GIQKH 61_ RTSLP 66_ APMFS 71_ RSDFS 76_ VWTIL 81_ KKCVG 86_ LELSK 91_ ITMPI 96_ AFNEP 101_ LSFLQ 106_ RITEY 111_ MEHVY 116_ LIHRA 121_ SCQPQ 126_ PLERM 131_ QSVAA 136_ FAVSA 141_ VASQW 146_ ERTGK 151_ PFNPL 156_ LGETY 161_ ELIRE 166_ DLGFR 171_ FISEQ 176_ VSHHP 181_ PISAF 186_ HSEGL 191_ NHDFL 196_ FHGSI 201_ YPKLK 206_ FWGKS 211_ VEAEP 216_ RGTIT 221_ LELLK 226_ HNEAY 231_ TWTNP 236_ TCCVH 241_ NVIIG 246_ KLWIE 251_ QYGTV 256_ EILNH 261_ RTGHK 266_ CVLHF 271_ KPCGL 276_ FGKEL 281_ HKVEG 286_ HIQDK 291_ NKKKL 296_ FMIYG 301_ KWTEC 306_ LWGID 311_ PVSYE 316_ SFKKQ 321_ ERRGD 326_ HLRKA 331_ KLDED 336_ SGKAD 341_ SDVAD 346_ DVPVA 351_ QETVQ 356_ VIPGS 361_ KLLWR 366_ INTRP 371_ PNSAQ 376_ MYNFT 381_ SFTVS 386_ LNELE 391_ TGMEK 396_ TLPPT 401_ DCRLR 406_ PDIRG 411_ MENGN 416_ MDLAS 421_ QEKER 426_ LEEKQ 431_ REARR 436_ ERAKE 441_ EAEWQ 446_ TRWFY 451_ PGNNP 456_ YTGTP 461_ DWLYA 466_ GDYFE 471_RNFSD
1: Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane (PubMed:30581148). Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate (PubMed:30581148). Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (PubMed:11279184). Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro) (PubMed:17428193, PubMed:19224871, PubMed:30581148)