Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 (Mitochondrial NAD(+) transporter SLC25A51) (Mitochondrial carrier triple repeat protein 1) (Solute carrier family 25 member 51)
1_MMDSE 6_ AHEKR 11_ PPILT 16_ SSKQD 21_ ISPHI 26_ TNVGE 31_ MKHYL 36_ CGCCA 41_ AFNNV 46_ AITFP 51_ IQKVL 56_ FRQQL 61_ YGIKT 66_ RDAIL 71_ QLRRD 76_ GFRNL 81_ YRGIL 86_ PPLMQ 91_ KTTTL 96_ ALMFG 101_ LYEDL 106_ SCLLH 111_ KHVSA 116_ PEFAT 121_ SGVAA 126_ VLAGT 131_ TEAIF 136_ TPLER 141_ VQTLL 146_ QDHKH 151_ HDKFT 156_ NTYQA 161_ FKALK 166_ CHGIG 171_ EYYRG 176_ LVPIL 181_ FRNGL 186_ SNVLF 191_ FGLRG 196_ PIKEH 201_ LPTAT 206_ THSAH 211_ LVNDF 216_ ICGGL 221_ LGAML 226_ GFLFF 231_ PINVV 236_ KTRIQ 241_ SQIGG 246_ EFQSF 251_ PKVFQ 256_ KIWLE 261_ RDRKL 266_ INLFR 271_ GAHLN 276_ YHRSL 281_ ISWGI 286_ INATY 291_EFLLK
1: Mitochondrial membrane carrier protein that mediates the import of NAD(+) into mitochondria (PubMed:32906142, PubMed:33087354, PubMed:33262325). Mitochondrial NAD(+) is required for glycolysis and mitochondrial respiration (PubMed:32906142, PubMed:33087354, PubMed:33262325). Compared to SLC25A52, SLC25A51-mediated transport is essential for the import of NAD(+) in mitochondria (PubMed:32906142). The transport mechanism, uniport or antiport, its electrogenicity and substrate selectivity, remain to be elucidated