Opsin-3 (Encephalopsin) (Panopsin)
1_MYSGN 6_ RSGGH 11_ GYWDG 16_ GGAAG 21_ AEGPA 26_ PAGTL 31_ SPAPL 36_ FSPGT 41_ YERLA 46_ LLLGS 51_ IGLLG 56_ VGNNL 61_ LVLVL 66_ YYKFQ 71_ RLRTP 76_ THLLL 81_ VNISL 86_ SDLLV 91_ SLFGV 96_ TFTFV 101_ SCLRN 106_ GWVWD 111_ TVGCV 116_ WDGFS 121_ GSLFG 126_ IVSIA 131_ TLTVL 136_ AYERY 141_ IRVVH 146_ ARVIN 151_ FSWAW 156_ RAITY 161_ IWLYS 166_ LAWAG 171_ APLLG 176_ WNRYI 181_ LDVHG 186_ LGCTV 191_ DWKSK 196_ DANDS 201_ SFVLF 206_ LFLGC 211_ LVVPL 216_ GVIAH 221_ CYGHI 226_ LYSIR 231_ MLRCV 236_ EDLQT 241_ IQVIK 246_ ILKYE 251_ KKLAK 256_ MCFLM 261_ IFTFL 266_ VCWMP 271_ YIVIC 276_ FLVVN 281_ GHGHL 286_ VTPTI 291_ SIVSY 296_ LFAKS 301_ NTVYN 306_ PVIYV 311_ FMIRK 316_ FRRSL 321_ LQLLC 326_ LRLLR 331_ CQRPA 336_ KDLPA 341_ AGSEM 346_ QIRPI 351_ VMSQK 356_ DGDRP 361_ KKKVT 366_ FNSSS 371_ IIFII 376_ TSDES 381_ LSVDD 386_ SDKTN 391_ GSKVD 396_VIQVR
1: G-protein coupled receptor which selectively activates G proteins via ultraviolet A (UVA) light-mediated activation in the skin (PubMed:28842328, PubMed:31097585, PubMed:31380578). Binds both 11-cis retinal and all-trans retinal (PubMed:31097585). Regulates melanogenesis in melanocytes via inhibition of alpha-MSH-induced MC1R-mediated cAMP signaling, modulation of calcium flux, regulation of CAMK2 phosphorylation, and subsequently phosphorylation of CREB, p38, ERK and MITF in response to blue light (PubMed:28842328, PubMed:31097585). Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling (PubMed:31730232). Additionally regulates apoptosis via cytochrome c release and subsequent activation of the caspase cascade (PubMed:31730232). Required for TYR and DCT blue light-induced complex formation in melanocytes (PubMed:28842328). Involved in keratinocyte differentiation in response to blue-light (PubMed:30168605). Required for the UVA-mediated induction of calcium and mitogen-activated protein kinase signaling resulting in the expression of MMP1, MMP2, MMP3, MMP9 and TIMP1 in dermal fibroblasts (PubMed:31380578). Plays a role in light-mediated glucose uptake, mitochondrial respiration and fatty acid metabolism in brown adipocyte tissues (By similarity). May be involved in photorelaxation of airway smooth muscle cells, via blue-light dependent GPCR signaling pathways (By similarity)