Tetraspanin-10 (Tspan-10) (Oculospanin)
1_MEEGE 6_ RSPLL 11_ SQETA 16_ GQKPL 21_ SVHRP 26_ PTSGC 31_ LGPVP 36_ REDQA 41_ EAWGC 46_ SCCPP 51_ ETKHQ 56_ ALSGT 61_ PKKGP 66_ APSLS 71_ PGSSC 76_ VKYLI 81_ FLSNF 86_ PFSLL 91_ GLLAL 96_ AIGLW 101_ GLAVK 106_ GSLGS 111_ DLGGP 116_ LPTDP 121_ MLGLA 126_ LGGLV 131_ VSAAS 136_ LAGCL 141_ GALCE 146_ NTCLL 151_ RGFSG 156_ GILAF 161_ LVLEA 166_ VAGAL 171_ VVALW 176_ GPLQD 181_ SLEHT 186_ LRVAI 191_ AHYQD 196_ DPDLR 201_ FLLDQ 206_ VQLGL 211_ RCCGA 216_ ASYQD 221_ WQQNL 226_ YFNCS 231_ SPGVQ 236_ ACSLP 241_ ASCCI 246_ DPRED 251_ GASVN 256_ DQCGF 261_ GVLRL 266_ DADAA 271_ QRVVY 276_ LEGCG 281_ PPLRR 286_ WLRAN 291_ LAASG 296_ GYAIA 301_ VVLLQ 306_ GAELL 311_ LAARL 316_ LGALA 321_ ARSGA 326_ AYGPG 331_ AHGED 336_ RAGPQ 341_ SPSPG 346_APPAA
1: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates