Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1)
1_MAAPL 6_ GGMFS 11_ GQPPG 16_ PPQAP 21_ PGLPG 26_ QASLL 31_ QAAPG 36_ APRPS 41_ SSTLV 46_ DELES 51_ SFEAC 56_ FASLV 61_ SQDYV 66_ NGTDQ 71_ EEIRT 76_ GVDQC 81_ IQKFL 86_ DIARQ 91_ TECFF 96_ LQKRL 101_ QLSVQ 106_ KPEQV 111_ IKEDV 116_ SELRN 121_ ELQRK 126_ DALVQ 131_ KHLTK 136_ LRHWQ 141_ QVLED 146_ INVQH 151_ KKPAD 156_ IPQGS 161_ LAYLE 166_ QASAN 171_IPAPL
1: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways