DNA replication factor Cdt1 (Double parked homolog) (DUP)
1_MEQRR 6_ VTDFF 11_ ARRRP 16_ GPPRI 21_ APPKL 26_ ACRTP 31_ SPARP 36_ ALRAP 41_ ASATS 46_ GSRKR 51_ ARPPA 56_ APGRD 61_ QARPP 66_ ARRRL 71_ RLSVD 76_ EVSSP 81_ STPEA 86_ PDIPA 91_ CPSPG 96_ QKIKK 101_ STPAA 106_ GQPPH 111_ LTSAQ 116_ DQDTI 121_ SELAS 126_ CLQRA 131_ RELGA 136_ RVRAL 141_ KASAQ 146_ DAGES 151_ CTPEA 156_ EGRPE 161_ EPCGE 166_ KAPAY 171_ QRFHA 176_ LAQPG 181_ LPGLV 186_ LPYKY 191_ QVLAE 196_ MFRSM 201_ DTIVG 206_ MLHNR 211_ SETPT 216_ FAKVQ 221_ RGVQD 226_ MMRRR 231_ FEECN 236_ VGQIK 241_ TVYPA 246_ SYRFR 251_ QERSV 256_ PTFKD 261_ GTRRS 266_ DYQLT 271_ IEPLL 276_ EQEAD 281_ GAAPQ 286_ LTASR 291_ LLQRR 296_ QIFSQ 301_ KLVEH 306_ VKEHH 311_ KAFLA 316_ SLSPA 321_ MVVPE 326_ DQLTR 331_ WHPRF 336_ NVDEV 341_ PDIEP 346_ AALPQ 351_ PPATE 356_ KLTTA 361_ QEVLA 366_ RARNL 371_ ISPRM 376_ EKALS 381_ QLALR 386_ SAAPS 391_ SPGSP 396_ RPALP 401_ ATPPA 406_ TPPAA 411_ SPSAL 416_ KGVSQ 421_ DLLER 426_ IRAKE 431_ AQKQL 436_ AQMTR 441_ CPEQE 446_ QRLQR 451_ LERLP 456_ ELARV 461_ LRSVF 466_ VSERK 471_ PALSM 476_ EVACA 481_ RMVGS 486_ CCTIM 491_ SPGEM 496_ EKHLL 501_ LLSEL 506_ LPDWL 511_ SLHRI 516_ RTDTY 521_ VKLDK 526_ AADLA 531_ HITAR 536_ LAHQT 541_RAEEG
1: Required for both DNA replication and mitosis (PubMed:11125146, PubMed:14993212, PubMed:21856198, PubMed:22581055, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC) (PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity)