ATP-binding cassette sub-family G member 8 (EC 7.6.2.-) (Sterolin-2)
1_MAGKA 6_ AEERG 11_ LPKGA 16_ TPQDT 21_ SGLQD 26_ RLFSS 31_ ESDNS 36_ LYFTY 41_ SGQPN 46_ TLEVR 51_ DLNYQ 56_ VDLAS 61_ QVPWF 66_ EQLAQ 71_ FKMPW 76_ TSPSC 81_ QNSCE 86_ LGIQN 91_ LSFKV 96_ RSGQM 101_ LAIIG 106_ SSGCG 111_ RASLL 116_ DVITG 121_ RGHGG 126_ KIKSG 131_ QIWIN 136_ GQPSS 141_ PQLVR 146_ KCVAH 151_ VRQHN 156_ QLLPN 161_ LTVRE 166_ TLAFI 171_ AQMRL 176_ PRTFS 181_ QAQRD 186_ KRVED 191_ VIAEL 196_ RLRQC 201_ ADTRV 206_ GNMYV 211_ RGLSG 216_ GERRR 221_ VSIGV 226_ QLLWN 231_ PGILI 236_ LDEPT 241_ SGLDS 246_ FTAHN 251_ LVKTL 256_ SRLAK 261_ GNRLV 266_ LISLH 271_ QPRSD 276_ IFRLF 281_ DLVLL 286_ MTSGT 291_ PIYLG 296_ AAQHM 301_ VQYFT 306_ AIGYP 311_ CPRYS 316_ NPADF 321_ YVDLT 326_ SIDRR 331_ SREQE 336_ LATRE 341_ KAQSL 346_ AALFL 351_ EKVRD 356_ LDDFL 361_ WKAET 366_ KDLDE 371_ DTCVE 376_ SSVTP 381_ LDTNC 386_ LPSPT 391_ KMPGA 396_ VQQFT 401_ TLIRR 406_ QISND 411_ FRDLP 416_ TLLIH 421_ GAEAC 426_ LMSMT 431_ IGFLY 436_ FGHGS 441_ IQLSF 446_ MDTAA 451_ LLFMI 456_ GALIP 461_ FNVIL 466_ DVISK 471_ CYSER 476_ AMLYY 481_ ELEDG 486_ LYTTG 491_ PYFFA 496_ KILGE 501_ LPEHC 506_ AYIII 511_ YGMPT 516_ YWLAN 521_ LRPGL 526_ QPFLL 531_ HFLLV 536_ WLVVF 541_ CCRIM 546_ ALAAA 551_ ALLPT 556_ FHMAS 561_ FFSNA 566_ LYNSF 571_ YLAGG 576_ FMINL 581_ SSLWT 586_ VPAWI 591_ SKVSF 596_ LRWCF 601_ EGLMK 606_ IQFSR 611_ RTYKM 616_ PLGNL 621_ TIAVS 626_ GDKIL 631_ SVMEL 636_ DSYPL 641_ YAIYL 646_ IVIGL 651_ SGGFM 656_ VLYYV 661_ SLRFI 666_KQKPS
1: ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11452359, PubMed:15054092, PubMed:27144356). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11452359, PubMed:15054092). The heterodimer with ABCG5 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356)