Olfactory receptor 51E2 (HPRAJ) (Olfactory receptor OR11-16) (Prostate-specific G-protein coupled receptor)
1_MSSCN 6_ FTHAT 11_ FVLIG 16_ IPGLE 21_ KAHFW 26_ VGFPL 31_ LSMYV 36_ VAMFG 41_ NCIVV 46_ FIVRT 51_ ERSLH 56_ APMYL 61_ FLCML 66_ AAIDL 71_ ALSTS 76_ TMPKI 81_ LALFW 86_ FDSRE 91_ ISFEA 96_ CLTQM 101_ FFIHA 106_ LSAIE 111_ STILL 116_ AMAFD 121_ RYVAI 126_ CHPLR 131_ HAAVL 136_ NNTVT 141_ AQIGI 146_ VAVVR 151_ GSLFF 156_ FPLPL 161_ LIKRL 166_ AFCHS 171_ NVLSH 176_ SYCVH 181_ QDVMK 186_ LAYAD 191_ TLPNV 196_ VYGLT 201_ AILLV 206_ MGVDV 211_ MFISL 216_ SYFLI 221_ IRTVL 226_ QLPSK 231_ SERAK 236_ AFGTC 241_ VSHIG 246_ VVLAF 251_ YVPLI 256_ GLSVV 261_ HRFGN 266_ SLHPI 271_ VRVVM 276_ GDIYL 281_ LLPPV 286_ INPII 291_ YGAKT 296_ KQIRT 301_ RVLAM 306_ FKISC 311_DKDLQ
1: Olfactory receptor (PubMed:27226631, PubMed:29249973). Activated by the odorant, beta-ionone, a synthetic terpenoid (PubMed:19389702, PubMed:27226631, PubMed:29249973). The activity of this receptor is probably mediated by G-proteins leading to the elevation of intracellular Ca(2+), cAMP and activation of the protein kinases PKA and MAPK3/MAPK1 (PubMed:27226631, PubMed:29249973). Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis (PubMed:27226631). Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells (PubMed:29249973). Activated also by the short-chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). Activated by L-lactate in glomus cells (By similarity)